10 Result(s)
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Roby P. Bhattacharyya
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Article
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING
The host type I interferon (IFN) pathway is a major signature of inflammation induced by the human fungal pathogen, Candida albicans. However, the molecular mechanism for activating this pathway in the host defen...
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Article
Open AccessInter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance
Carbapenem-resistant Enterobacterales (CRE) are an urgent global health threat. Inferring the dynamics of local CRE dissemination is currently limited by our inability to confidently trace the spread of resistanc...
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Article
Preventing Infectious Complications of Immunomodulation in COVID-19 in Foreign-Born Patients
Immunomodulating therapies for COVID-19 may carry risks of reactivating latent infections in foreign-born people. We conducted a rapid review of infection-related complications of immunomodulatory therapies fo...
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An immune-cell signature of bacterial sepsis
Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition with high mortality. Multiple whole-blood gene-expression studies have defined sepsis-associated molecular signatures...
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Open AccessHybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis
Dual transcriptional profiling of host and bacteria during infection is challenging due to the low abundance of bacterial mRNA. We report Pathogen Hybrid Capture (PatH-Cap), a method to enrich for bacterial mR...
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Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination
Multidrug resistant organisms are a serious threat to human health1,2. Fast, accurate antibiotic susceptibility testing (AST) is a critical need in addressing escalating antibiotic resistance, since delays in ide...
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Open AccessRapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA
Rapid bacterial identification remains a critical challenge in infectious disease diagnostics. We developed a novel molecular approach to detect and identify a wide diversity of bacterial pathogens in a single...
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Open AccessHigh-throughput automated microfluidic sample preparation for accurate microbial genomics
Low-cost shotgun DNA sequencing is transforming the microbial sciences. Sequencing instruments are so effective that sample preparation is now the key limiting factor. Here, we introduce a microfluidic sample ...
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Simultaneous generation of many RNA-seq libraries in a single reaction
RNAtag-seq barcodes transcripts prior to cDNA synthesis, thereby allowing pooled library generation from many input samples.
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Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis
β-Lactams are one of the most useful classes of antibiotics against many common bacterial pathogens. One exception is Mycobacterium tuberculosis. However, with increasing incidence of multidrug-resistant tubercul...
