14 Result(s)
within
Markus Kleinewietfeld
-
Article
Salt sensitivity includes effects on immune cell signalling and metabolism
Excess salt (sodium chloride) intake is a risk factor for hypertension and is attributed to increasing rates of morbidity and mortality from cardiovascular diseases. Salt sensitivity is classically defined as ...
-
Article
Open AccessFatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis (MS). Emerging evidence indicates that endogenous and dietary-induced cha...
-
Article
Open AccessGlutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells
The metabolic principles underlying the differences between follicular and marginal zone B cells (FoB and MZB, respectively) are not well understood. Here we show, by studying mice with B cell-specific ablatio...
-
Article
Improving the Efficacy of Regulatory T Cell Therapy
Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-specific to system disorders. Patients with autoimmune diseases are commonly treated with broad-acting immunomodulatory ...
-
Article
Open AccessFasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome ex...
-
Article
Sodium in the microenvironment regulates immune responses and tissue homeostasis
During tissue inflammation, immune cells infiltrate the interstitial space of target organs, where they sense and adapt to local environmental stimuli. Such stimuli include not only pathogens but also local fa...
-
Article
Salt-responsive gut commensal modulates TH17 axis and disease
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to...
-
Article
Open AccessImpact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation
There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidenc...
-
Article
Open AccessEnvironmental factors in autoimmune diseases and their role in multiple sclerosis
An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiati...
-
Article
Sodium chloride, SGK1, and Th17 activation
The incidence of autoimmune diseases in Western civilizations is increasing rapidly, suggesting an influence of environmental factors, such as diet. The pathogenesis of several of these autoimmune diseases is ...
-
Article
Genetic and epigenetic fine map** of causal autoimmune disease variants
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-map** algorithm to identify c...
-
Article
Role of “Western Diet” in Inflammatory Autoimmune Diseases
Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized coun...
-
Article
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimenta...
-
Article
Induction and molecular signature of pathogenic TH17 cells
Exposure to interleukin 23 (IL-23) is required for the induction of pathogenic TH17 cells. Kuchroo and colleagues show that IL-23-dependent induction of the cytokine TGF-β3 produces a molecular signature characte...
