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Article
A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion
Fluorescence resonance energy transfer (FRET) reporters are commonly used in the final stages of nucleic acid amplification tests to indicate the presence of nucleic acid targets, where fluorescence is restore...
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Article
Open AccessNew infundibulopelvic angle measurement method can predict stone-free rates following retrograde intrarenal surgery
To enhance the accuracy of predicting stone-free rates after retrograde intrarenal surgery, we devised a novel approach to assess the renal infundibulopelvic angle. We conducted a retrospective review of patie...
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Article
Open AccessNeurobiologically realistic neural network enables cross-scale modeling of neural dynamics
Fundamental principles underlying computation in multi-scale brain networks illustrate how multiple brain areas and their coordinated activity give rise to complex cognitive functions. Whereas brain activity h...
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Article
Correction to: Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells
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Article
Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells
The reprogramming of cellular metabolism is a hallmark of cancer. The ability to noninvasively assay glucose and lactate concentrations in cancer cells would improve our understanding of the dynamic changes in...
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Article
Open AccessGenerative adversarial network enables rapid and robust fluorescence lifetime image analysis in live cells
Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to quantify molecular compositions and study molecular states in complex cellular environment as the lifetime readings are not biased by fluor...
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Article
Open AccessTumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to...
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Article
Open AccessThe impact of urine microbiota in patients with lower urinary tract symptoms
Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of ...
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Article
Open AccessEndoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients...
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Article
Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy
Inconsistent prognostic implications of body mass index (BMI) in upper tract urothelial carcinoma (UTUC) have been reported across different ethnicities. In this study, we aimed to analyze the oncologic role o...
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Article
Risk of develo** hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study
BackgroundAndrogen deprivation therapy (ADT) is essential in the treatment of advanced and metastatic prostate cancer. As the correlation between hormone therapy and hypertension remains unclear and prostate canc...
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Article
Open AccessAssessing metastatic potential of breast cancer cells based on EGFR dynamics
Derailed transmembrane receptor trafficking could be a hallmark of tumorigenesis and increased tumor invasiveness, but receptor dynamics have not been used to differentiate metastatic cancer cells from less in...
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Article
Open AccessThe diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence
To clarify if diagnostic ureteroscopy (URS) before radical nephroureterectomy for patients with upper tract urothelial carcinoma (UTUC) will increase the risk of intravesical recurrence.
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Article
Open AccessTwo-color multiphoton in vivo imaging with a femtosecond diamond Raman laser
Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength tuning. However, most ...
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Article
Open AccessLower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipo...
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Article
Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer
Bladder cancer (BC) is the most common malignancy in urinary system. The prognosis of metastatic BC is poor, but there remains no reliable marker to early detect metastasis. Dysregulated prenylated protein tyr...
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Article
Laparoscopic partial nephrectomy without intracorporeal suturing
Partial nephrectomy has gained wider acceptance as a surgical technique in treating small renal tumors. Laparoscopic partial nephrectomy (LPN) still remains a technically demanding surgery to this day. We pres...
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Article
Open AccessDeep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination
Molecular trafficking within cells, tissues and engineered three-dimensional multicellular models is critical to the understanding of the development and treatment of various diseases including cancer. However...
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Article
Comparison one-step procedure with two-step procedure in percutaneous nephrolithotomy
The aim of this study was to compare the effects of one-step percutaneous nephrolithotomy (PCNL) by the urologist alone and two-step PCNL by cooperating with the radiologist. We included 168 patients who unde...
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Chapter
Single Molecule DNA Detection
The development of single-molecule detection (SMD) technologies that allow measurements of intra and intermolecular interactions at the most fundamental level has greatly advanced basic research in biophysics ...
