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Article
Open AccessPolyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeosta...
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Article
Open AccessThe role of Lon-mediated proteolysis in the dynamics of mitochondrial nucleic acid-protein complexes
Mitochondrial nucleoids consist of several different groups of proteins, many of which are involved in essential cellular processes such as the replication, repair and transcription of the mitochondrial genome...
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Article
Open AccessThe N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease
Lon is an essential, multitasking AAA+ protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to se...
