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Article
Open AccessDNA methylation age acceleration is associated with risk of diabetes complications
Patients with Type 2 diabetes mellitus (T2D) are at risk for micro- and macrovascular complications. Implementable risk scores are needed to improve targeted prevention for patients that are particularly susce...
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Article
Diagnostik und Therapie von statinassoziierten Muskelsymptomen
Statine zählen zu den am häufigsten verordneten Medikamenten deutschlandweit. Ihr Nutzen in der Senkung des kardiovaskulären Risikos ist unbestritten. Dennoch klagen viele Patienten über Nebenwirkungen unter S...
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Article
Open AccessLow muscle strength and increased arterial stiffness go hand in hand
Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross...
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Article
Open AccessT cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II
Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiolog...
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Article
Open AccessRelationship between Lipoprotein (a) and cognitive function – Results from the Berlin Aging Study II
It has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)]...
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Article
Open AccessHyperlipidemias in elderly patients: results from the Berlin Aging Study II (BASEII), a cross-sectional study
Hyperlipidemias are common and the last decades have seen substantially growing evidence of their causative role in the development of atherosclerosis and subsequent cardiovascular diseases. Since hyperlipidem...
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Type II diabetes and dementia
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Frailty and the Metabolic Syndrome — Results of the Berlin Aging Study II (BASE-II)
Frailty and the metabolic Syndrome (MetS) are frequently found in old subjects and have been associated with increased risk of functional decline and dependency. Moreover, central characteristics of the MetS l...
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Article
Different treatment forms of type II diabetes and the risk of dementia in German health claims data
The association between type II diabetes (T2D) and increased all-cause dementia risk is well established. However, to date, there is no definite proof that a specific therapy for diabetes can halt a progress o...
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Open AccessProblematic drinking in the old and its association with muscle mass and muscle function in type II diabetes
Problematic drinking behavior is common in the old and negative consequences of hypoglycemic episodes in type 2 diabetes (T2D) as a result of alcohol consumption have been described previously. Although, assoc...
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Article
Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin
Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nat...
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Article
Angiotensin-Converting Enzyme Inhibitors and Parameters of Sarcopenia: Relation to Muscle Mass, Strength and Function: Data from the Berlin Aging Study-II (BASE-II)
Pharmacological options for the treatment of sarcopenia currently do not exist. However, off-label treatment options of some established drugs have been suggested.
