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Open AccessAprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature
Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global...
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Open AccessDefinitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer
Preclinical and clinical studies suggest potential synergy between high dose per fraction focal radiation and immunotherapy. However, conventionally fractionated radiation regimens in combination with concurre...
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Open AccessImmunologic profiling of adenoid cystic carcinoma (acc)
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Open AccessEarly mortality and overall survival in oncology phase I trial participants: can we improve patient selection?
Patient selection for phase I trials (PIT) in oncology is challenging. A typical inclusion criterion for PIT is 'life expectancy > 3 months', however the 90 day mortality (90DM) and overall survival (OS) of pa...
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Open AccessThe association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
We examine the potential prognostic and predictive roles of EGFR variant III mutation, EGFR gene copy number (GCN), human papillomavirus (HPV) infection, c-MET and p16 INK4A