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Article
Corrosion Mechanism of Three-Dimensional Network Configuration SiC–Fe Composites in Deep Mine Environment
With the development and depletion of shallow coal resources, deep coal mining has gradually become normalized. In the face of increasingly severe corrosion environment of coal mining, it is urgent to develop ...
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Chapter and Conference Paper
Novel Bayesian Network Incremental Learning Method Based on Particle Swarm Optimization Algorithm
Traditional bayesian network learning mainly uses batch learning method, that is, assuming that the training data can be acquired in one time, the whole learning process will end after learning these samples. ...
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Article
Open AccessCarnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway
Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with high prevalence in humans. Carnosic acid (CA) has been reported to possess antioxidative properties; however, its role in IBDs...
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Article
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage
Cathepsin L is a lysosomal cysteine protease that plays important roles in cancer tumorigenesis, proliferation and chemotherapy resistance. The aim of this study was to determine how cathepsin L regulated the ...
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Article
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-κB signaling pathway
Cathepsin L, a lysosomal cysteine proteinase, is exclusively elevated in a variety of malignancies, including gliomas. In this study we investigated the relationship between cathepsin L and NF-κB, two radiatio...
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Article
NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro
NVP-BEZ235 is a novel dual PI3K/mTOR inhibitor and shows dramatic effects on gliomas. The aim of this study was to investigate the effects of NVP-BEZ235 on the radiosensitivity and autophagy of glioma stem cel...
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Article
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
Rac is a small GTPase of the Rho family that mediates stimulus-induced actin cytoskeletal reorganization to generate lamellipodia1,2,3,4,5. Little is known about the signalling pathways that link Rac activation t...
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Article
Inhibition of activated Ras-induced neuronal differentiation of PC12 cells by the LIM domain of LIM-kinase 1
LIM-kinase 1 and 2 (LIMK1 and LIMK2) are members of a novel class of protein kinases with structures composed of two LIM motifs at the N-terminus and an unusual protein kinase domain at the C-terminus. The cel...
