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Article
Open AccessHOXA4 protein levels and localization in the aorta and in human abdominal aortic aneurysms
This report presents evidence for the specificities of select commercially available HOXA4 antibodies in regards to concerns about the specificity of the HOXA4 antibody used by Lillvis et al. (Regional expression...
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Article
Open AccessHOX cofactors expression and regulation in the human ovary
HOX cofactors enhance HOX binding affinities and specificities and increase HOX's unique functional activities. The expression and the regulation of HOX cofactors in human ovaries are unknown.
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Chapter
Ovarian Cancer: Linking Genomics to New Target Discovery and Molecular Markers — The Way Ahead
Epithelial ovarian cancer (EOC) is the 4th leading cause of cancer deaths among USA women and the most common cause of death from gynecologic cancers (1,2). It arises from ovarian surface epithelial (OSE) cell...
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Article
Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion
Ovarian cancer is the most lethal of all gynecological cancers. Most deaths from ovarian cancer are due to widespread intraperitoneal metastases and malignant ascites. However, mechanisms of invasion in ovaria...
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Article
An improved assay to quantitate the invasiveness of cells in modified Boyden chambers
The most commonly used means of assessing the invasiveness of cultured cells is the Boyden chamber assay, which requires that cells lyse Matrigel™, followed by migration through pores in a filter in response t...
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Chapter
Potential Role of Gonadotropin-Releasing Hormone and Estrogen in Ovarian Cancer
In addition to its well-documented role in the reproductive hormone cascade, GnRH may play a role as an autocrine/paracrine regulator in the inhibition of cell proliferation and/or induction of apoptosis in no...
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Article
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
High-density array comparative genomic hybridization (CGH)1 showed amplification of chromosome 1q22 centered on the RAB25 small GTPase2, which is implicated in apical vesicle trafficking3, in approximately half o...
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Article
Open AccessOvarian surface epithelium: family history and early events in ovarian cancer
Ovarian cancer is the most common cause of death from gynecological cancers in the Western world. There are many genetic and environmental factors which can influence a woman's risk of getting ovarian cancer. ...
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Article
Open AccessMitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surfa...
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Article
Differential effects of cellular fibronectin and plasma fibronectin on ovarian cancer cell adhesion, migration, and invasion
The main form of fibronectin (FN) encountered by tumor cells in vivo is cellular FN (cFN), which differs structurally and functionally from the commonly used plasma FN (pFN). We compared the effects of cFN and...
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Article
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential
Although early stage ovarian cancer can be effectively treated with surgery and chemotherapy, the majority of cases present with advanced disease, which remains essentially incurable. Unfortunately, little is ...
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Chapter
Normal Ovarian Surface Epithelium
The ovarian surface epithelium (OSE) is the part of the pelvic mesothelium that covers the ovary. It is also referred to in the literature as ovarian mesothelium (OM) (1, 2) or normal ovarian epithelium (NOE) ...
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Article
Differentiation and growth potential of human ovarian surface epithelial cells expressing temperature-sensitive SV40 T antigen
The epithelial ovarian carcinomas arise in the ovarian surface epithelium (OSE) which is the mesothelial covering of the ovary. Studies of human OSE have been hampered by the small amounts and limited lifespan...
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Protocol
Culture and Characterization of Human Ovarian Surface Epithelium
The ovarian surface epithelium (OSE) is the part of the pelvic mesothelium that covers the ovary. It comprises only a minute fraction of the ovary-however, it is the source of the epithelial ovarian carcinomas...
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Article
Metaplastic changes in cultured human ovarian surface epithelium
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Article
Efficient introduction of genes into human ovarian surface epithelium
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Article
A line of rat ovarian surface epithelium provides a continuous source of complex extracellular matrix
A spontaneously immortalized, yet non-tumorigenic rat ovarian surface epithelial (ROSE 199) cell line, deposits large amounts of extracellular matrix (ECM) in response to crowding. The characteristics and comp...
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Article
Quantifiable cell suspensions from fixed, stained monolayers grown in culture
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Article
Percoll centrifugation eliminates mold contaminants from cell cultures
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Article
Density separation of rat adrenocortical cells: Morphology, steroidogenesis, and P-450scc expression in primary culture
We have developed a method that separates rat adrenocortical cells by density into populations which retain zone specific properties in primary culture. Two different parenchymal populations were obtained and ...
