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  1. Article

    Open Access

    Pvt1-encoded microRNAs in oncogenesis

    The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loc...

    Gabriele B Beck-Engeser, Amy M Lum, Konrad Huppi, Natasha J Caplen… in Retrovirology (2008)

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  2. No Access

    Article

    RNAi quashes polyQ

    RNA interference in the brain inhibits neurodegeneration in a polyglutamine disease, SCA1. Is this now the way forward for the clinical treatment of certain genetic disorders (pages 816–820

    Natasha J Caplen in Nature Medicine (2004)

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    Article

    Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

    We report the results of a double-blind, placebo-controlled trial in nine cystic fibrosis (CF) subjects receiving cationic liposome complexed with a complementary DNA encoding the CF transmembrane conductance ...

    Natasha J. Caplen, Eric W.F.W. Alton, Peter G. Mddleton, Julia R. Dorin… in Nature Medicine (1995)