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Article
Open AccessTranscriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains
Mouse models are useful for studying cigarette smoke (CS)-induced chronic pulmonary pathologies such as lung emphysema. To enhance translation of large-scale omics data from mechanistic studies into pathophysi...
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Protocol
Using a Crowdsourcing Approach for Network Verification
Biological network models have many applications in systems toxicology and in biomarker and target identification for drug discovery. A critical challenge is to keep the models relevant and representative of c...
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Article
Open AccessA vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability
Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of ...
