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Open AccessDeep learning reconstruction for high-resolution computed tomography images of the temporal bone: comparison with hybrid iterative reconstruction
We investigated whether the quality of high-resolution computed tomography (CT) images of the temporal bone improves with deep learning reconstruction (DLR) compared with hybrid iterative reconstruction (HIR).
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Article
Open AccessGGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis
Post-ERCP pancreatitis (PEP) is an acute pancreatitis caused by endoscopic-retrograde-cholangiopancreatography (ERCP). About 10% of patients develop PEP after ERCP. Here we show that gamma-glutamyltransferase ...
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Article
Open AccessAdverse Events as Potential Predictive Factors of Activity in Patients with Advanced HCC Treated with Atezolizumab Plus Bevacizumab
In the context of patients with hepatocellular carcinoma (HCC) treated with systemic therapy, the correlation between the appearance of adverse events (AEs) and reported efficacy outcomes is well-known and wid...
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Article
Open AccessExtracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer
One drawback of existing artificial intelligence (AI)-based histopathological prediction models is the lack of interpretability. The objective of this study is to extract p16-positive oropharyngeal squamous ce...
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Article
Open AccessPressure dependence of metal–silicate partitioning explains the mantle phosphorus abundance
Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), DP, extrapolated to typical high-pressure and -temperature conditions of the Earth’s core for...
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Article
Open AccessApplication of polyglycolic acid sheets and basic fibroblast growth factor to prevent esophageal stricture after endoscopic submucosal dissection in pigs
Endoscopic submucosal dissection (ESD) has been the first-line treatment for early-stage esophageal cancer. However, it often causes postoperative stricture in cases requiring wide dissection. Basic fibroblast...
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Article
Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis
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Open AccessL-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
Oncometabolites, such as D/L-2-hydroxyglutarate (2HG), have directly been implicated in carcinogenesis; however, the underlying molecular mechanisms remain poorly understood. Here, we showed that the levels of...
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Article
Open AccessA dehydrated space-weathered skin cloaking the hydrated interior of Ryugu
Without a protective atmosphere, space-exposed surfaces of airless Solar System bodies gradually experience an alteration in composition, structure and optical properties through a collective process called sp...
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Article
Open AccessUsefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome
Sinusoidal obstruction syndrome (SOS) refers to liver injury caused by hematopoietic stem cell transplantation (HSCT) and anticancer drugs including oxaliplatin. Increased splenic volume (SV) on computed tomog...
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Article
Open AccessSerum IL-1β predicts de novo hepatitis B virus reactivation during direct-acting antiviral therapy for hepatitis C, not during anti-cancer/immunosuppressive therapy
De novo hepatitis B virus (HBV) reactivation occurs during direct-acting antiviral (DAA) treatment in hepatitis C virus (HCV)-infected patients with resolved HBV infection. We evaluated the predictive factors,...
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Article
Open AccessMulticenter, prospective, observational study of chemotherapy-induced dysgeusia in gastrointestinal cancer
Dysgeusia is an adverse event caused by chemotherapy. Although retrospective studies have shown zinc administration improves dysgeusia, there have been no prospective studies. The present study examined effect...
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Open AccessOptical biopsy for esophageal squamous cell neoplasia by using endocytoscopy
Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet u...
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Article
Open AccessCOVID-19-associated leukoencephalopathy in the absence of severe hypoxia with subsequent improvement: a case report
Several cases of coronavirus disease 2019 (COVID-19)-associated leukoencephalopathy have been reported. Although most cases involve hypoxia, the pathophysiological mechanism and neurologic outcomes of COVID-19...
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Open AccessArtificial intelligence (AI) models for the ultrasonographic diagnosis of liver tumors and comparison of diagnostic accuracies between AI and human experts
Ultrasonography (US) is widely used for the diagnosis of liver tumors. However, the accuracy of the diagnosis largely depends on the visual perception of humans. Hence, we aimed to construct artificial intelli...
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Article
Open AccessPrediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication
Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed t...
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Article
Open AccessEradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to in...
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Article
Open AccessShallow magmatic processes revealed by cryptic microantecrysts: a case study from the Taupo Volcanic Zone
Arc magmas typically contain phenocrysts with complex zoning and diverse growth histories. Microlites highlight the same level of intracrystalline variations but require nanoscale resolution which is globally ...
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Article
Establishment of oxaliplatin-resistant gastric cancer organoids: importance of myoferlin in the acquisition of oxaliplatin resistance
The attainment of drug resistance in gastric cancer (GC) is a problematic issue. Although many studies have shown that cancer stem cells (CSCs) play an important role in the acquisition of drug resistance, the...
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Open AccessPossible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients...
