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Article
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through increased Notch signalling.
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Article
The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are a group of diseases that present with the paradox of cytopenia despite a cellular bone marrow. This can be explained by exc...
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Article
Open AccessPrediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome
Approximately 70% of all patients with myelodysplastic syndrome (MDS) present with lower-risk disease. Some of these patients will initially respond to treatment with growth factors to improve anemia but will ...
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Article
Open AccessPhase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS)
Ezatiostat, a glutathione S-transferase P1-1 inhibitor, promotes the maturation of hematopoietic progenitors and induces apoptosis in cancer cells.
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Article
Cigarette smoking shortens the survival of patients with low-risk myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are a group of hematological malignancies with poor survival. Although previous studies have identified the prognostic role of multiple demographic and clinical characteristics,...
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Article
Open AccessOral Ezatiostat HCl (TLK199) and Myelodysplastic syndrome: A case report of sustained hematologic response following an abbreviated exposure
Treatment options for patients with lower risk non-del(5q) myelodysplastic syndromes (MDS) who fail erythroid stimulating agents are restricted to one of the hypomethylating drugs with an expected response rat...
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Article
Open AccessPhase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome
Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and...
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Article
Open AccessIsolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)
In a departure from conventional strategies to improve treatment outcome for myeloid malignancies, we report the isolation of leukemia-specific peptides using a phage display library screened with freshly obta...
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Article
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient t...
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Article
Prognosis in myelodysplastic syndromes: Are the new classifications useful?
Increased understanding of the biologic and clinical parameters that define subgroups of myelodysplastic syndromes has led to continuing refinement of classification strategies for diagnostic and prognostic us...
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Article
Lenalidomide for myelodysplastic syndromes: finally, hope not hype
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Article
Increased Levels and Activity of E2F1 Transcription Factor in Myelodysplastic Bone Marrow
The bone marrow of patients with myelodysplastic syndromes (MDS) shows excessive intramedullary apoptosis, particularly in S-phase cells. In the light of previous reports that showed a link between experimenta...
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Article
Biological Significance of Proliferation, Apoptosis, Cytokines, and Monocyte/Macrophage Cells in Bone Marrow Biopsies of 145 Patients With Myelodysplastic Syndrome
Labeling index (LI), apoptosis, levels of 2 pro-apoptotic cytokines tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β), and the number of monocyte/macrophage cells that are the likely sou...
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Article
Sequence-ready physical map of the mouse Chromosome 16 region with conserved synteny to the human Velocardiofacial syndrome region on 22q11.2
Proximal mouse Chromosome (Chr) 16 shows conserved synteny with human Chrs 16, 8, 22, and 3. The mouse Chr 16/human Chr 22 conserved synteny region includes the DiGeorge/Velocardiofacial syndrome region of hu...
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Article
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma. The chromosome 13 gene (FKHR) is identified as a member ...
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Article
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
We have determined that PAX3 (found previously to be mutated in Waardenburg syndrome) is the chromosome 2 locus rearranged by the t(2;13)(q35;q14) translocation of the paediatric solid tumour alveolar rhabdomyosa...
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Article
Epstein-Barr Virus-Transformed B-Cell Line (DV-1) Derived from Bone Marrow of a Patient with Severe Combined Immunodeficiency and Immunoblastic Lymphoma
ABSTRACT: An Epstein-Barr virus-transformed B-cell line derived from a patient with severe combined immunodeficiency who died of a lymphoreticular malignancy has been characterized. The line derived from bone ...
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Article
Effects of isolated tumor lymphocytes alone and with adherent cells
The effect on the growth of gradient-isolated mouse mammary tumor cells of different populations of lymphoid cells were evaluated in micrototoxicity assays. Variable effects were obtained with tumor-bearer lym...
