22 Result(s)

Article

Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have promising potential for opening new avenues in regenerative medicine. However, since the tumorigenic potential of undifferentiated pl...

Toshinobu Nishimura, Haojun Xu, Masayuki Iwasaki, Daiki Karigane… in Gene Therapy (2020)

Article

The path to retinoblastoma

Genomic analyses of tumours of the childhood cancer retinoblastoma reveal a low mutation rate, challenging the view that genomic instability is crucial for its progression. The work also identifies a new thera...

Julien Sage, Michael L. Cleary in Nature (2012)

Article

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

MLL fusion oncogenes are pathogenically associated with 5–10% of human acute leukemias. Through multiple interactions with chromatin regulatory factors, they convert a normal hematopoietic hierarchy into a leu...

Tim C. P. Somervaille, Michael L. Cleary in International Journal of Hematology (2010)

Article

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase that participates in numerous signalling pathways involved in diverse physiological processes. Several of these pathways are impli...

Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille… in Nature (2008)

Article

Protein arginine-methyltransferase-dependent oncogenesis

Enzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression¹ and oncogenesis^2,3, but also provide potential targets for molecular therapy⁴. Although...

Ngai Cheung, Li Chong Chan, Alex Thompson, Michael L Cleary… in Nature Cell Biology (2007)

Chapter and Conference Paper

Search for Genes Involved Central Respiratory Failure Using Mice Models

To search for genes that cause human congenital respiratory failure, we undertook several studies using wild type mice and gene-deficient mice that exhibit respiratory failure. 1) To assess respiratory abnorma...

Satoru Arata, Hiroshi Onimaru, Akiko Arata… in Breathing, Feeding, and Neuroprotection (2006)

Article

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

Pbx1 is a member of the TALE (three–amino acid loop extension) class of homeodomain transcription factors^1,2, which are components of hetero-oligomeric protein complexes thought to regulate developmental gene exp...

Seung K. Kim, Licia Selleri, Joon S. Lee, Andrew Y. Zhang, Xueying Gu… in Nature Genetics (2002)

Article

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. These translocations result in a gain of MLL function by generating novel chimeric pr...

Paul M Ayton, Michael L Cleary in Oncogene (2001)

Article

HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis

Specific Hox genes are implicated in leukemic transformation, and their selective genetic collaboration with TALE homeobox genes, Pbx and Meis, accentuates their oncogenic potential. The molecular mechanisms unde...

Catherine A Schnabel, Yakop Jacobs, Michael L Cleary in Oncogene (2000)

Article

A new angle on a pervasive oncogene

Michael L Cleary in Nature Genetics (1999)

Article

Association of SET domain and myotubularin-related proteins modulates growth control

Several proteins that contribute to epigenetic mechanisms of gene regulation contain a characteristic motif of unknown function called the SET (Suvar3-9, Enhancer-of-zeste, Trithorax) domain. We have demonstrated...

**angmin Cui, Immaculata De Vivo, Robert Slany, Alison Miyamoto… in Nature Genetics (1998)

Article

Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice

Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes t...

Brian J Feldman, Tony R Reid, Michael L Cleary in Oncogene (1997)

Article

Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53-independent mechanism that is suppressed by Bcl-2

The chimeric oncoprotein E2a-Pbx1 results from fusion of the E2A and PBX1 genes following t(1;19) chromosomal translocations in B cell precursor acute leukemias. Experimentally B cell progenitors do not tolerate ...

Kevin S Smith, Yakop Jacobs, Ching-Pin Chang, Michael L Cleary in Oncogene (1997)

Chapter

PCR Assessment of the Efficacy of Therapy in Philadelphia Chromosome-Positive Leukemias

As discussed in Chapter 31, the PCR has rapidly assumed an important role in the molecular diagnosis of cancer. Neoplastic transformation is accompanied by a series of somatic genetic mutations that culminate ...

Stephen P. Hunger, Michael L. Cleary in The Polymerase Chain Reaction (1994)

Article

Telomeric structure in cells with chromosome end associations

End-to-end associations of metaphase chromosomes have been observed in a variety of human tumors, ageing cells, and several chromosome instability syndromes. Since telomeres of tumor cells and ageing tissues a...

David Saltman, Rodman Morgan, Michael L. Cleary, Titia de Lange in Chromosoma (1993)

Article

Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2

THE bcl-2 gene is consistently associated with t(14; 18) chromosomal translocations^1–6 observed in a large fraction of human B-cell lymphomas^7–8. The t(14; 18) translocation results in deregulated expression of t...

Katherine Monica, Zehava Chen-Levy, Michael L. Cleary in Nature (1990)