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  1. Article

    Open Access

    VISTA and its ligands: the next generation of promising therapeutic targets in immunotherapy

    V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative checkpoint receptor (NCR) primarily involved in maintaining immune tolerance. It has a role in the pathogenesis of autoimmune...

    Najibeh Shekari, Dariush Shanehbandi, Tohid Kazemi… in Cancer Cell International (2023)

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    Article

    Combination Therapy with KRAS and P38α siRNA Suppresses Colorectal Cancer Growth and Development in SW480 Cell Line

    Colorectal cancer (CRC) is one of the most prevalence malignancies in a different society with a high rate of death. The KRAS and p38α axes have critical roles in the development, migration, and growth of nume...

    Shiva Kamran, Ensiyeh Seyedrezazadeh… in Journal of Gastrointestinal Cancer (2022)

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    Article

    DHA Abolishes the Detrimental Effect of Docetaxel on Downregulation of the MICA via Decreasing the Expression Level of MicroRNA-20a in Gastric Cancer

    MHC class I chain-related protein A (MICA) is a membrane glycoprotein expressed abnormally on some malignant cells including gastric cancer (GC) cell and elicits anti-tumor immune responses. Downregulation of ...

    Najibeh Shekari, Mahsa Javadian, Sima Ghaffari… in Journal of Gastrointestinal Cancer (2020)

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    Article

    Synergistic Beneficial Effect of Docosahexaenoic Acid (DHA) and Docetaxel on the Expression Level of Matrix Metalloproteinase-2 (MMP-2) and MicroRNA-106b in Gastric Cancer

    Gastric cancer (GC) is one of the most common cancers with the majority of patients recognized in advanced stages. The efficacy of using docosahexaenoic acid (DHA) as a supplementary agent has been suggested i...

    Najibeh Shekari, Mahsa Javadian, Mottahareh Ghasemi… in Journal of Gastrointestinal Cancer (2020)