10 Result(s)
within
Cell Biology
Stem Cells
Naihe **g
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Article
Open AccessContinuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...
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Open AccessGeneration of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...
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Open AccessThe therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obs...
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Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
In the version of this Article originally published, the first name of author Guangdun Peng was spelled incorrectly as Guangdum. This has now been amended in all versions of the Article.
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Article
Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
The morphogenetic remodelling of embryo architecture after implantation culminates in pro-amniotic cavity formation. Despite its key importance, how this transformation occurs remains unknown. Here, we apply h...
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Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions...
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Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
Embryonic stem cells can be incorporated into the develo** embryo and its germ line, but, when cultured alone, their ability to generate embryonic structures is restricted. They can interact with trophoblast...
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Open AccessAF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation
AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However, AF9 function and related mechanisms in human neurode...
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Article
Secretion of polypeptides related to epidermal growth factor and insulinlike growth factor I by a human teratocarcinoma cell line
To identify polypeptide growth factors for human teratocarcinoma cells, we studied the malignant ovarian teratoma-derived cell line, PA-1, that grew autonomously in serum-free medium. Medium conditioned by und...
