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  1. Article

    Open Access

    Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria

    Cemdisiran, an N-acetylgalactosamine (GalNAc) conjugated RNA interference (RNAi) therapeutic, is currently under development for the treatment of complement-mediated diseases by suppressing liver production of co...

    Prajakta Badri, Xuemin Jiang, Anna Borodovsky, Nader Najafian… in Clinical Pharmacokinetics (2021)

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  2. Article

    Open Access

    In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

    Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25+ FoxP3+ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmun...

    Leslie P. Cousens, Nader Najafian, Federico Mingozzi… in Journal of Clinical Immunology (2013)

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