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Article
Open AccessPharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Cemdisiran, an N-acetylgalactosamine (GalNAc) conjugated RNA interference (RNAi) therapeutic, is currently under development for the treatment of complement-mediated diseases by suppressing liver production of co...
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Article
Open AccessIn Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity
Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25+ FoxP3+ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmun...
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T Cell Epitopes of Phl p 1, Major Pollen Allergen of Timothy Grass (Phleum pratense)
Recently several group I grass pollen allergens, such as Phl p 1 from timothy grass (Phleum pratense), some isoforms of Loi p 1 from rye-grass (Lolium perenne), and Sec c 1 from rye (Secale cereale; S. Laffler, u...