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  1. Article

    Open Access

    Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

    Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs. We used a computational drug repositioning strategy to uncover a novel therapy for NASH, identifying a GABA-B receptor...

    Dipankar Bhattacharya, Christine Becker, Benjamin Readhead… in Scientific Reports (2021)

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  2. No Access

    Chapter

    Novel Methods for Addressing Immunogenicity of Therapeutic Enzymes

    While the biotechnology revolution has contributed to the development of life-saving replacement proteins for blood factor and enzyme such as hemophilia and Pompe disease, these therapies can induce immune res...

    Leslie P. Cousens, Leonard Moise, Anne S. De Groot M.D. in Biobetters (2015)

  3. Article

    Open Access

    In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

    Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25+ FoxP3+ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmun...

    Leslie P. Cousens, Nader Najafian, Federico Mingozzi… in Journal of Clinical Immunology (2013)

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  4. No Access

    Article

    Mechanistic and antineoplastic evaluation of taurolidine in the DU145 model of human prostate cancer

    Taurolidine (TRD) was designed in the 1970s as a broad-spectrum antibiotic and is used clinically at high doses without systemic toxicity. We have found that this agent possesses cytotoxic activity in human tu...

    James W. Darnowski, Frederick A. Goulette… in Cancer Chemotherapy and Pharmacology (2004)

  5. No Access

    Article

    Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

    Induction of high systemic levels of type 1 interferons (IFNs) IFN-α and IFN-β is a hallmark of many viral infections. In addition to their potent antiviral effects, these cytokines mediate a number of immunor...

    Khuong B. Nguyen, Leslie P. Cousens, Lesley A. Doughty, Gary C. Pien… in Nature Immunology (2000)

  6. No Access

    Chapter

    Early Cytokine Responses to Viral Infections and Their Roles in Sha** Endogenous Cellular Immunity

    Immune responses to different infectious agents have overlap** constituents. However, certain of these are induced to higher levels and/or play more important roles in defense under conditions of infections ...

    Christine A. Biron, Leslie P. Cousens… in Mechanisms of Lymphocyte Activation and Im… (1998)