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Article

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25⁺ FoxP3⁺ T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmun...

Leslie P. Cousens, Nader Najafian, Federico Mingozzi… in Journal of Clinical Immunology (2013)