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Article
GABA transporter 1 transcriptional starting site exhibiting tissue specific difference
GABA transporter 1(GAT1) takes important roles in multiple physiological processes through the uptake and release of GABA, but the regulation of GAT1 gene expression in different tissues is rarely known. To ad...
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Article
Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand
It was suggested that chronic ethanol exposure could result in testicular germ cell apoptosis, but the mechanism is still unclear. In the present study, we use a model of transgenic mice ubiquitously overexpre...
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Article
Impaired reproduction in transgenic mice overexpressing γ-aminobutyric acid transporter I (GAT1)
It is well documented that γ-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosom...
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Article
Open AccessStructure and domain organization of Drosophila Tudor
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Article
Open AccessStructure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
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Article
Open AccessIn vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models
NZ2114 is a promising candidate for therapeutic application owing to potent activity to gram-positive bacterium such as Streptococcus pneumoniae and Staphylococcus aureus. This work is the first report to describ...
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Investigation of elastic constants and ultimate strengths of Korean pine from compression and tension tests
Korean pine (Pinus koraiensis) is a wood species recently adopted in China for the rehabilitation of traditional timber buildings. This paper investigates its mechanical properties with laboratory tests on typica...
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Open AccessArchitecture of SWI/SNF chromatin remodeling complex
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Open AccessLong non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats
The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.
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Article
Open AccessApolipoprotein E polymorphisms contribute to statin response in Chinese ASCVD patients with dyslipidemia
Apolipoprotein E (ApoE) plays an important role in lipid metabolism and clearance. Statins are the most common drugs used to modulate the lipid profile in the clinic therapy; the associations between ApoE poly...
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Article
Open AccessDevelopment of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli
Pathogenic Escherichia coli can cause fatal diarrheal diseases in both animals and humans. However, no antibiotics or antimicrobial peptides (AMPs) can adequately kill resistant bacteria and clear bacterial endot...
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Open AccessTranscriptome analysis reveals the defense mechanism of cotton against Verticillium dahliae in the presence of the biocontrol fungus Chaetomium globosum CEF-082
Verticillium wilt of cotton is a serious soil-borne disease that causes a substantial reduction in cotton yields. A previous study showed that the endophytic fungus Chaetomium globosum CEF-082 could control Verti...
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Therapeutic potential of a designed CSαβ peptide ID13 in Staphylococcus aureus-induced endometritis of mice
Staphylococcus aureus is a common pathogen that can cause clinical and subclinical endometritis in humans and animals. In this study, a designed CSαβ peptide ID13 from DLP4 exhibited high stable antibacterial act...
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Open AccessDynamic changes of lipid profile in severe hypertriglyceridemia-induced acute pancreatitis patients under double filtration plasmapheresis: a retrospective observational study
To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain the association between...
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Article
Open AccessLong-term effects of mixed planting on arbuscular mycorrhizal fungal communities in the roots and soils of Juglans mandshurica plantations
Establishing mixed plantations is an effective way to improve soil fertility and increase forest productivity. Arbuscular mycorrhizal (AM) fungi are obligate symbiotic fungi that can promote mineral nutrient a...
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Article
Open AccessSpontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development
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Article
Open AccessC-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo
Enteropathogenic Escherichia coli and Salmonella pullorum are two important groups of zoonotic pathogens. At present, the treatment of intestinal pathogenic bacteria infection mainly relies on antibiotics, which ...
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Open AccessLong-term watermelon continuous crop** leads to drastic shifts in soil bacterial and fungal community composition across gravel mulch fields
Despite the known influence of continuous crop** on soil microorganisms, little is known about the associated difference in the effects of continuous crop** on the community compositions of soil bacteria a...
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Article
Open AccessRibosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progression of various malignancies, however, the role of RPL5 in colon cancer...
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Article
Open AccessLong non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1
Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of card...