77 Result(s)

Article

Pharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model

Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study ...

Xueling Zheng, Na Yang, Ruoyu Mao, Ya Hao… in Applied Microbiology and Biotechnology (2024)

Article

TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53

Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myoca...

Shiyu Gong, Ming Zhai, Jiayun Shi, Guanye Yu, Zhijun Lei… in Cell Death & Differentiation (2024)

Article

Recent advances in targeted protein degraders as potential therapeutic agents

Targeted protein degradation (TPD) technology has gradually become widespread in the past 20 years, which greatly boosts the development of disease treatment. Contrary to small inhibitors that act on protein k...

Na Yang, Bo Kong, Zhaohong Zhu, Fei Huang, Liliang Zhang, Tao Lu… in Molecular Diversity (2024)

Article

Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside

Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies,...

Beibei Zhang, Mengzhe Yang, Weiming Zhang, Ning Liu, Daogang Wang… in Cell Death & Disease (2024)

Article

Expression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus

The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The improvement of activity and yield through modification and heterologous expression, a potential way to solve the problem, ...

Kun Zhang, Na Yang, Da Teng, Ruoyu Mao, Ya Hao… in Applied Microbiology and Biotechnology (2024)

Article

Genome-wide identification and expression pattern analysis of the kiwifruit GRAS transcription factor family in response to salt stress

GRAS is a family of plant-specific transcription factors (TFs) that play a vital role in plant growth and development and response to adversity stress. However, systematic studies of the GRAS TF family in kiwi...

Ling Zhu, Tuo Yin, Mengjie Zhang, **uyao Yang, Jiexin Wu, Hanbing Cai… in BMC Genomics (2024)

Article

A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Pathogenic Escherichia coli is one of the most common causes of diarrhea diseases and its characteristic component of the outer membrane-lipopolysaccharide (LPS) is a major inducer of sepsis. Few drugs have been ...

Zhenlong Wang, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, **umin Wang… in Communications Biology (2023)

Article

Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced ne...

**g Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li… in Stem Cell Research & Therapy (2023)

Article

Increased age, bilirubin, international normalized ratio, and creatinine score to triglyceride ratio are associated with alcohol-associated primary liver carcinoma: a single-centered retrospective study

This study analyzed the clinical features and biomarkers of alcohol-associated liver disease (ALD) to investigate the diagnostic value of age, bilirubin, international normalized ratio (INR), and creatinine (A...

**aoqing Jia, Rong Li, **aoting Zhang, Tao Zhou, Dalong Sun… in Lipids in Health and Disease (2023)

Article

Lactoferrin, a Great Wall of host-defence?

Jianhua Wang, Na Yang, Hans J. Vogel in BioMetals (2023)

Article

Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1

Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of card...

Rui Yang, Liangliang Li, Yumeng Hou, Yingnan Li, **g Zhang… in Cell Death & Disease (2023)

Article

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway

Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progression of various malignancies, however, the role of RPL5 in colon cancer...

Huahua Zhang, Junli Liu, Qingqing Dang, Xueru Wang… in BMC Molecular and Cell Biology (2022)

Article

Long-term watermelon continuous crop** leads to drastic shifts in soil bacterial and fungal community composition across gravel mulch fields

Despite the known influence of continuous crop** on soil microorganisms, little is known about the associated difference in the effects of continuous crop** on the community compositions of soil bacteria a...

**n Gu, Na Yang, Yan Zhao, Wenhui Liu, Tingfeng Li in BMC Microbiology (2022)