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  1. No Access

    Article

    Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells

    Structure/functional studies previously reported showed that in a series of simple organic cations in which the charge is delocalized, an aromatic ring and a minimal degree of lipophilicity (log P > −1) were r...

    TJ Lampidis, Y-F Shi, CL Calderon, D Kolonias, H Tapiero, N Savaraj in Leukemia (1997)

  2. No Access

    Article

    Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

    Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by...

    W-B Tsai, Y Long, J-R Park, J T Chang, H Liu, J Rodriguez-Canales, N Savaraj… in Oncogene (2016)