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Article
Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents
Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by...
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Article
Open AccessNegative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
Arginine-depleting therapy with pegylated arginine deiminase (ADI-PEG20) was reported to have activity in advanced melanoma in early phase I–II trial, and clinical trials are currently underway in other cancer...
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Article
Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells
Structure/functional studies previously reported showed that in a series of simple organic cations in which the charge is delocalized, an aromatic ring and a minimal degree of lipophilicity (log P > −1) were r...
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Chapter
Selectivity and Localization of Anthracyclines in Cardiac-Muscle and Non-Muscle Cells Relevance to Multidrug Resistance
Cardiac-muscle (CM) vs cardiac non-muscle (NM) cells (fibroblasts) have been shown to preferentially accumulate positively-charged anthracyclines (AT) (1), xanthene dyes (2), and other organic cations (3). It ...
