21 Result(s)

Article

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling

Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatment...

X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George… in Oncogene (2017)

Article

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by...

W-B Tsai, Y Long, J-R Park, J T Chang, H Liu, J Rodriguez-Canales, N Savaraj… in Oncogene (2016)

Article

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

The four R-spondins (RSPO1–4) and their three related receptors LGR4, 5 and 6 (LGR4–6) have emerged as a major ligand-receptor system with critical roles in development and stem cell survival through modulatio...

X Gong, J Yi, K S Carmon, C A Crumbley, W **ong, A Thomas, X Fan, S Guo, Z An… in Oncogene (2015)

Article

GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer

The epithelial–mesenchymal transition (EMT) bestows cancer cells with increased stem cell properties and metastatic potential. To date, multiple extracellular stimuli and transcription factors have been shown ...

T R Sarkar, V L Battula, S J Werden, G V Vijay, E Q Ramirez-Peña, J H Taube… in Oncogene (2015)

Article

Grp78 as a therapeutic target for refractory head–neck cancer with CD24⁻CD44⁺ stemness phenotype

Cancer stem cells are refractory to conventional therapy, which result to cancer metastasis and chemo-radioresistance. Grp78 is known to have important roles in cytoprotection and tumorigenesis in several canc...

C-C Chiu, L-Y Lee, Y-C Li, Y-J Chen, Y-C Lu, Y-L Li, H-M Wang… in Cancer Gene Therapy (2013)

Article

Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is activated by cigarette smoke. Previously, we demonstrated that AhR is overexpressed in lung adenocarcinomas (ADs). In this stu...

P-H Chen, H Chang, J T Chang, P Lin in Oncogene (2012)

Article

Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-κB activation

Apurinic endonuclease 1 (Ape1) is not only involved in base excision repair, but also activates some transcriptional factors through its redox activity. However, which subcellular localization of Ape1 is invol...

H-H Wu, Y-W Cheng, J T Chang, T-C Wu, W-S Liu, C-Y Chen, H Lee in Oncogene (2010)

Article

Anchorage-independent cell growth signature identifies tumors with metastatic potential

The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic mutations that lead to the deregulation of growth regulatory and cell fate controlling activities and pathways. The abili...

S Mori, J T Chang, E R Andrechek, N Matsumura, T Baba, G Yao, J W Kim, M Gatza… in Oncogene (2009)

Article

A combinatorial mechanism for determining the specificity of E2F activation and repression

Various studies have detailed the role of E2F proteins in both transcription activation and repression. Further study has shown that distinct promoter elements, but comprising the same E2F-recognition motif, c...

J A Freedman, J T Chang, L Jakoi, J R Nevins in Oncogene (2009)

Article

Compensation and specificity of function within the E2F family

Functions encoded by single genes in lower organisms are often represented by multiple related genes in the mammalian genome. An example is the retinoblastoma and E2F families of proteins that regulate transcr...

L-J Kong, J T Chang, A H Bild, J R Nevins in Oncogene (2007)

Article

DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis

To identify genes that could potentially serve as molecular therapeutic markers for human head and neck cancer (HNC), we employed differential display analysis to compare the gene expression profiles between H...

Y-J Chen, J T Chang, L Lee, H-M Wang, C-T Liao, C-C Chiu, P-J Chen, A-J Cheng in Oncogene (2007)

Article

No evidence of porcine endogenous retrovirus infection in bioartificial skin composed of porcine dermal matrix

 Xenotransplantation of pig organs and tissues to humans involves a risk of infection by porcine endogenous retrovirus (PERV). This investigation examined potential transmission of PERV by using an in vitro cu...

J.-T. Chang, M.-S. Lin, Y.-C. Chou, M.-J. Yang, S.-R. Wang in Journal of Artificial Organs (2002)

Article

Integrating genotype and phenotype information: an overview of the PharmGKB project

T E Klein, J T Chang, M K Cho, K L Easton, R Fergerson… in The Pharmacogenomics Journal (2001)

Article

Electroplating of Ni-Cr on steel with pulse plating

It has been difficult to electrolytically obtain crack- free chromium plating because of the high stresses caused by several factors. Accordingly, electroplating of nickel- chromium also encounters a similar p...

K-L Lin, C-J Hsu, I-M Hsu, J-T Chang in Journal of Materials Engineering and Performance (1992)