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  1. Article

    Open Access

    Confirmation of novel type 1 diabetes risk loci in families

    Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were ide...

    J. D. Cooper, J. M. M. Howson, D. Smyth, N. M. Walker, H. Stevens… in Diabetologia (2012)

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  2. No Access

    Article

    Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3–q14.1

    A candidate gene study was conducted on 10 established type II diabetes genes and 45 genes associated with autoimmune diseases, including type I diabetes (T1D), in a maximum of 1410 affected sib-pair families ...

    J D Cooper, N M Walker, B C Healy, D J Smyth, K Downes, J A Todd in Genes & Immunity (2009)

  3. No Access

    Article

    Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families

    The advent of genome-wide association (GWA) studies has revolutionized the detection of disease loci and provided abundant evidence for previously undetected disease loci that can be pooled together in meta-an...

    J D Cooper, N M Walker, D J Smyth, K Downes, B C Healy, J A Todd in Genes & Immunity (2009)

  4. No Access

    Article

    Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families

    In recent years the pace of discovery of genetic associations with type I diabetes (T1D) has accelerated, with the total number of confirmed loci, including the major histocompatibility complex (MHC) region, r...

    J M M Howson, N M Walker, D J Smyth, J A Todd in Genes & Immunity (2009)

  5. Article

    Open Access

    No association of multiple type 2 diabetes loci with type 1 diabetes

    We used recently confirmed type 2 diabetes gene regions to investigate the genetic relationship between type 1 and type 2 diabetes, in an average of 7,606 type 1 diabetic individuals and 8,218 controls, provid...

    S. M. Raj, J. M. M. Howson, N. M. Walker, J. D. Cooper, D. J. Smyth… in Diabetologia (2009)

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  6. No Access

    Article

    Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

    As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to individual immune-mediated diseases, as well as evidence t...

    E Y M G Fung, D J Smyth, J M M Howson, J D Cooper, N M Walker… in Genes & Immunity (2009)

  7. No Access

    Article

    CD226 Gly307Ser association with multiple autoimmune diseases

    Genome-wide association studies provide insight into multigenic diseases through the identification of susceptibility genes and etiological pathways. In addition, the identification of shared variants among au...

    J P Hafler, L M Maier, J D Cooper, V Plagnol, A Hinks, M J Simmonds… in Genes & Immunity (2009)

  8. Article

    Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls

    S. F. Field, J. M. M. Howson, N. M. Walker, D. B. Dunger, J. A. Todd in Diabetologia (2007)

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  9. Article

    Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

    S. F. Field, J. M. M. Howson, D. J. Smyth, N. M. Walker, D. B. Dunger… in Diabetologia (2007)

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  10. Article

    Erratum: Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

    Nat. Genet. 37, 110–111 (2005). The authors' affiliations were mistakenly omitted. A complete list of authors and their affiliations follows. Deborah J Smyth1, Joanna M M Howson1, Christopher E Lowe1, Neil M W...

    D J Smyth, J M M Howson, C E Lowe, N M Walker, A C Lam, S Nutland… in Nature Genetics (2005)

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  11. No Access

    Article

    Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

    Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy ...

    L M Maier, R C J Twells, J M M Howson, A C Lam, D G Clayton, D J Smyth… in Genes & Immunity (2003)

  12. No Access

    Article

    An evaluation of the use of proton pump inhibitors

    Objectives: To review whether Proton Pump Inhibitors (PPIs) are prescribed for appropriate indications and to assess the quality of information being supplied to GPs on discharge. Method: Prospective study of 85...

    N.M. Walker, J. McDonald in Pharmacy World and Science (2001)