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  1. Article

    Open Access

    Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases

    Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in ad...

    J. M. M. Howson, S. Krause, H. Stevens, D. J. Smyth, J. M. Wenzlau… in Diabetologia (2012)

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  2. No Access

    Article

    Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3–q14.1

    A candidate gene study was conducted on 10 established type II diabetes genes and 45 genes associated with autoimmune diseases, including type I diabetes (T1D), in a maximum of 1410 affected sib-pair families ...

    J D Cooper, N M Walker, B C Healy, D J Smyth, K Downes, J A Todd in Genes & Immunity (2009)

  3. No Access

    Article

    Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families

    The advent of genome-wide association (GWA) studies has revolutionized the detection of disease loci and provided abundant evidence for previously undetected disease loci that can be pooled together in meta-an...

    J D Cooper, N M Walker, D J Smyth, K Downes, B C Healy, J A Todd in Genes & Immunity (2009)

  4. No Access

    Article

    Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families

    In recent years the pace of discovery of genetic associations with type I diabetes (T1D) has accelerated, with the total number of confirmed loci, including the major histocompatibility complex (MHC) region, r...

    J M M Howson, N M Walker, D J Smyth, J A Todd in Genes & Immunity (2009)

  5. Article

    Open Access

    No association of multiple type 2 diabetes loci with type 1 diabetes

    We used recently confirmed type 2 diabetes gene regions to investigate the genetic relationship between type 1 and type 2 diabetes, in an average of 7,606 type 1 diabetic individuals and 8,218 controls, provid...

    S. M. Raj, J. M. M. Howson, N. M. Walker, J. D. Cooper, D. J. Smyth… in Diabetologia (2009)

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  6. No Access

    Article

    Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

    As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to individual immune-mediated diseases, as well as evidence t...

    E Y M G Fung, D J Smyth, J M M Howson, J D Cooper, N M Walker… in Genes & Immunity (2009)

  7. Article

    Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

    S. F. Field, J. M. M. Howson, D. J. Smyth, N. M. Walker, D. B. Dunger… in Diabetologia (2007)

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  8. Article

    Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900–905

    L. M. Maier, J. D. Cooper, N. Walker, D. J. Smyth, J. A. Todd in Diabetologia (2005)

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  9. Article

    Erratum: Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

    Nat. Genet. 37, 110–111 (2005). The authors' affiliations were mistakenly omitted. A complete list of authors and their affiliations follows. Deborah J Smyth1, Joanna M M Howson1, Christopher E Lowe1, Neil M W...

    D J Smyth, J M M Howson, C E Lowe, N M Walker, A C Lam, S Nutland… in Nature Genetics (2005)

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  10. No Access

    Article

    Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

    Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy ...

    L M Maier, R C J Twells, J M M Howson, A C Lam, D G Clayton, D J Smyth… in Genes & Immunity (2003)

  11. No Access

    Article

    Selectable marker-free transgenic barley producing a high level of cellulase (1,4-β-glucanase) in develo** grains

    The use of barley grains as bioreactors for high-level production of cellulase (1,4-β-glucanase) was investigated. A hybrid cellulase gene, cel-hyb1, driven by the rice GluB-1 promoter was expressed specifically ...

    G. P. Xue, M. Patel, J. S. Johnson, D. J. Smyth, C. E. Vickers in Plant Cell Reports (2003)

  12. No Access

    Article

    Are Hodrick-Prescott `forecasts' rational?

    We evaluate the usefulness of the Hodrick-Prescott (HP) filter as a proxy for rational expectations, using long runs of annual US inflation data. Our conclusion is that while the HP series are not fully ratio...

    J. C. K. Ash, J. Z. Easaw, S. M. Heravi, D. J. Smyth in Empirical Economics (2002)

  13. No Access

    Article

    Temperature-regulated expression of the tac/lacI system for overproduction of a fungal xylanase in Escherichia coli

    Temperature-regulated expression of recombinant proteins in the tac promoter (Ptac) system was investigated. Expression levels of fungal xylanase and cellulase from N. patriciarum in E. coli strains containing th...

    G. -P. Xue, J. S. Johnson, D. J. Smyth… in Applied Microbiology and Biotechnology (1996)