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Article
Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma-associated herpesvirus to promote cell survival and persistent infection
Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication. EVs and viruses share several properties related to their structure and the biogenesis machinery in cells. EVs from virus-infecte...
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Article
Diverse Gene Expressions in the Prediction of Cuprizone-Induced Demyelination
Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (...
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Article
Open AccessNogo receptor–vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme
Nogo receptor (NgR) has been shown to inhibit the migration and invasion of human glioma cells. However, little is known regarding the regulatory mechanisms of NgR in glioblastoma multiforme (GBM). In this stu...
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Article
The effect of storage temperature on the biological activity of extracellular vesicles for the complement system
Extracellular vesicles (EVs) are mediators of intercellular communication by transporting cargo containing proteins, lipids, mRNA, and miRNA. There is increasing evidence that EVs have various roles in regulat...
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Article
Open AccessActivation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors
There is increasing evidence that the complement system is activated in various cancer tissues. Besides being involved in innate immunity against pathogens, the complement system also participates in inflammat...
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Article
Latent Kaposi’s sarcoma-associated herpesvirus infection in bladder cancer cells promotes drug resistance by reducing reactive oxygen species
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major etiologic agent of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. Recent studies have indicated that KSHV can be ...
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Article
The role of Kaposi’s sarcoma-associated herpesvirus infection in the proliferation of human bladder cancer cells
Existing evidence suggests a possible role of viruses in human bladder cancer development. Recently, Kaposi’s sarcoma-associated herpesvirus (KSHV) was reported to be the most frequently detected virus in blad...
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Article
Kaposi’s sarcoma-associated herpesvirus infection of human bone-marrow-derived mesenchymal stem cells and their angiogenic potential
Kaposi’s sarcoma (KS) is a vascular tumor, and KS spindle cells express endothelial-cell-specific markers. Generally, it is believed that KS originates from endothelial cells. However, as various mesodermal-de...
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Article
Kaposi’s sarcoma-associated herpesvirus infection of endothelial progenitor cells impairs angiogenic activity in vitro
A recent study reported that endothelial progenitor cells (EPCs0 are one of the reservoirs of Kaposi’s sarcoma associated herpesvirus (KSHV). Although EPCs are closely linked to angiogenesis and vasculogenesis...
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Article
Effects of the Ultra Low Diluted Ceria-Based Slurry on the Planarization Characteristics of Multi-Layer Exposed Surfaces
Planarization characteristics of ultra low diluted Ceria (CeO2) based slurry, especially a multi-layered Chemical Mechanical Polishing (CMP) process, have been studied. The multilayer represents the polished film...
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Article
Cell-free production of functional antibody fragments
Botulinum neurotoxin serotype B (BoNT/B)-specific Fab was expressed in a cell-free protein synthesis system derived from an E. coli extract. The cell-free synthesized antibody fragment was found to be effective i...
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Article
Generation of a naïve/synthetic antibody specific to botulinum neurotoxin via motif-grafting
In this study, we describe a new approach to the production of naïve/synthetic human antibodies against the botulinum neurotoxin (BoNT). First, peptides that bind to BoNT serotype A (BoNT/A) were screened from...
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Article
A pseudoknot improves selection efficiency in ribosome display
The size and diversity of ribosome display libraries depends upon stability of the complex formed between the ribosome, mRNA and translated protein. To investigate if mRNA secondary structure improves stabilit...
