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β-1,3-d-glucan lentinan/Poly-dA40 triple-helical complex in dilute solutions
Lentinan (Len) is a linear (1,3)-β-d-glucan with two of its five main-chain glucose-bearing (1,6)-β-d-glucan side chains. Like other β-d-glucans, Len is expected to form stoichiometric complexes with single-stran...
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Article
Delivery of therapeutic oligonucleotides targeting Dectin-1 using quantized complexes
Finding an appropriate carrier for antisense oligonucleotides (AS-ODNs) and improving the efficiency of their delivery to cells and organs has been critical for the translation of antisense therapy into practi...
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Article
Open AccessAn acute phase protein α1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action
The molecular mechanism for acute kidney injury (AKI) and its progression to chronic kidney disease (CKD) continues to be unclear. In this study, we investigated the pathophysiological role of the acute phase ...
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Article
Open AccessEffect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial
In this multicentre double-blind randomized clinical trial, we investigated the effects of oral cholecalciferol supplementation on serum hepcidin and parameters related to anaemia and CKD-MBD among haemodialys...
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Article
Open AccessA synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein
Renal fibrosis is a major factor in the progression of chronic kidney disease and the final common pathway of kidney injury. Therefore, the effective therapies against renal fibrosis are urgently needed. The o...
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Article
Open AccessA downstream molecule of 1,25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis
Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated with unremitting renal inflammation. Although it is reported that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the act...
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Article
Open AccessIndoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1
Skeletal muscle atrophy, referred to as sarcopenia, is often observed in chronic kidney disease (CKD) patients, especially in patients who are undergoing hemodialysis. The purpose of this study was to determin...
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Book
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Chapter
Introduction
In human histories, it has long been God/gods who are said to have created the universe and who will end it; both G/genesis and eschatology have belonged to the realm of religious literature. Narratives of the...
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Chapter
Apocalyptic Imagination after 2011
At 2:46 pm on March 11, 2011, a magnitude 9 earthquake struck the western Pacific Ocean at a depth of thirty-two kilometers. Its epicenter was approximately seventy-two kilometers east of the Oshika Peninsula ...
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Chapter
Conclusion
We have seen that there was an apocalyptic tradition in premodern Japan, but that it was less influential than the Western apocalyptic tradition. In Japan, the cyclical idea of time, which was introduced by Bu...
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Chapter
Apocalypse in Japan
We turn now to theory and criticism of apocalyptic thought and narrative in modern Japan from 1868 to 1945 (the beginning of the Meiji period to the end of World War II); from 1945 to 1970 (Japan’s defeat in W...
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Chapter
Apocalyptic Science Fiction in 1980s Japan
As we saw in Chapter Two, 1970 is viewed as a turning point in Japanese cultural trends. Ōsawa terms the period from that year to 1995 the fictional age, when Japanese culture gradually shifted from struggling...
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Chapter
The Trajectory of Apocalyptic Discourse
“Apocalypse,” “the end of the world,” “millennialism,” “millenarianism,” and “fin de siècle” are all terminologies of ending: of life, epochs, the world, and the universe.1 Among these end-related terms, apocalyp...
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Chapter
Apocalyptic Science Fiction from 1945 to the 1970s
From the early days of Japan’s modern period, apocalyptic narratives warned of problems caused by progressivism and modernization: ecological change, economic gaps between advanced and less advanced nations, e...
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Chapter
Apocalyptic Science Fiction after 1995—Sekaikei Works
Two apocalyptic events in 1995—the Kobe Earthquake and the sarin gas attack on the Tokyo subway—revealed not just the fragility of the Japanese infrastructure and emergency system that had previously been thou...
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Article
Open AccessToll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses
Since the beginning of the 20th century, humans have experienced four influenza pandemics, including the devastating 1918 'Spanish influenza'. Moreover, H5N1 highly pathogenic avian influenza (HPAI) viruses ar...
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Reference Work Entry In depth
Hypophosphatemia
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Article
The kidney and bone metabolism: Nephrologists' point of view
The kidney plays an important role in the regulatory system for bone and mineral metabolism. In chronic kidney disease (CKD), various abnormalities, recently named CKD-mineral and bone disorder (CKD-MBD), may ...
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Article
Effect of Telmisartan on Ambulatory Blood Pressure Monitoring, Plasma Brain Natriuretic Peptide, and Oxidative Status of Serum Albumin in Hemodialysis Patients
The effect of telmisartan on ambulatory blood pressure, plasma neurohormonal parameters, and oxidation of serum albumin has not been investigated in hemodialysis (HD) patients. Thirteen hypertensive HD patient...
