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  1. No Access

    Chapter

    Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms

    Oligonucleotide-based therapeutics may be one of the most promising approaches for the treatment of diseases. Although significant progress has been made in develo** these agents as drugs, several hurdles re...

    Ramon Eritja, Montserrat Terrazas, Santiago Grijalvo… in Chemical Biology of Nucleic Acids (2014)

  2. No Access

    Article

    Synthesis and properties of small interfering RNA duplexes carrying 5-ethyluridine residues

    Oligoribonucleotides carrying 5-ethyluridine units were prepared using solid-phase phosphoramidite chemistry. The introduction of the tert-butyldimethylsilyl group at the 2′-OH position proceeded in good yield an...

    Montserrat Terrazas, Ramon Eritja in Molecular Diversity (2011)

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    Protocol

    Synthesis of Oligonucleotide–Peptide Conjugates for Biomedical and Technological Applications

    Oligonucleotide–peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides c...

    Anna Aviñó, Santiago Grijalvo, Sónia Pérez-Rentero… in Bioconjugation Protocols (2011)