4 Result(s)
within
Modesto Orozco
Biochemistry, general
Biological Microscopy
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Article
Molecular strip** underpins derepression of a toxin–antitoxin system
Transcription factors control gene expression; among these, transcriptional repressors must liberate the promoter for derepression to occur. Toxin–antitoxin (TA) modules are bacterial elements that autoregulat...
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Article
Deciphering the mechanical code of the genome and epigenome
Diverse DNA-deforming processes are impacted by the local mechanical and structural properties of DNA, which in turn depend on local sequence and epigenetic modifications. Deciphering this mechanical code (tha...
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Article
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution
The linear sequence of DNA provides invaluable information about genes and their regulatory elements along chromosomes. However, to fully understand gene function and regulation, we need to dissect how genes p...
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Article
Visualizing phosphodiester-bond hydrolysis by an endonuclease
Different catalytic steps of endonuclease I-DmoI are captured crystallographically to allow direct observation of the generation of a DNA double-strand break. A third metal ion enters the active site and has a...
