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Article
Assembly of 43 human Y chromosomes reveals extensive complexity and variation
The prevalence of highly repetitive sequences within the human Y chromosome has prevented its complete assembly to date1 and led to its systematic omission from genomic analyses. Here we present de novo assemblie...
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Article
Open AccessAuthor Correction: Comparative and demographic analysis of orang-utan genomes
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Article
Toward tangibles and display-rich interfaces for co-located and distributed genomics collaborations
We discuss and present design probes investigating how pervasive displays could offer unique opportunities for enhancing discovery and learning with “big data.” Our collaboration across three universities unde...
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Article
Open AccessAlu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry
Baboons (genus Papio) and geladas (Theropithecus gelada) are now generally recognized as close phylogenetic relatives, though morphologically quite distinct and generally classified in separate genera. Primate sp...
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Article
Open AccessA computational reconstruction of Papio phylogeny using Alu insertion polymorphisms
Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for stud...
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Chapter
Weaving Peripheral Interaction Within Habitable Architectures
As researchers and practitioners seek to operationalize peripheral interaction, many key questions remain unresolved. Where might such technologically mediated interventions best be deployed? What might they l...
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Article
Open AccessAn integrated map of structural variation in 2,504 human genomes
Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising bo...
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Article
Open AccessTangram: a comprehensive toolbox for mobile element insertion detection
Mobile elements (MEs) constitute greater than 50% of the human genome as a result of repeated insertion events during human genome evolution. Although most of these elements are now fixed in the population, so...
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Article
Open AccessGibbon genome and the fast karyotype evolution of small apes
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we prese...
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Article
Open AccessOrangutan Alu quiescence reveals possible source element: support for ancient backseat drivers
Sequence analysis of the orangutan genome revealed that recent proliferative activity of Alu elements has been uncharacteristically quiescent in the Pongo (orangutan) lineage, compared with all previously studied...
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Article
Open AccessAlu pair exclusions in the human genome
The human genome contains approximately one million Alu elements which comprise more than 10% of human DNA by mass. Alu elements possess direction, and are distributed almost equally in positive and negative stra...
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Article
Map** copy number variation by population-scale genome sequencing
Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution arc...
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Article
Open AccessComparative and demographic analysis of orang-utan genomes
The genome of the Southeast Asian great ape or orang-utan has been sequenced — specifically a draft assembly of a Sumatran female individual and short-read sequence data from five further Sumatran and five Bor...
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Article
Open AccessThe genome of a songbird
The genome of the zebra finch — a songbird and a model for the study of vertebrate brain, behaviour and evolution — has been sequenced. Its comparison with the chicken genome, the only other bird genome availa...
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Protocol
Computational Methods for the Analysis of Primate Mobile Elements
Transposable elements (TE), defined as discrete pieces of DNA that can move from one site to another site in genomes, represent significant components of eukaryotic genomes, including primates. Comparative gen...
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Article
Erratum: Genome analysis of the platypus reveals unique signatures of evolution
Nature 453, 175–183 (2008) In this Article, Mikhail Nefedov and Pieter J. de Jong were omitted from the author list.
