4 Result(s)
within
Mira Ayadi
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessPacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma
Two tumor (Classical/Basal) and stroma (Inactive/active) subtypes of Pancreatic adenocarcinoma (PDAC) with prognostic and theragnostic implications have been described. These molecular subtypes were defined by...
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Article
Open AccessIntegrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting prognoses. These tumors are defined by recurrent mutations in the IDH genes and other genetic alterations including inactivat...
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Article
Open AccessDissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on histology and molecular profiling. Histology addresses inter-tumor and intra-tumor heterogeneity in MPM and describes three maj...
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Article
Open AccessDistinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying ep...
