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Article
Open AccessPacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma
Two tumor (Classical/Basal) and stroma (Inactive/active) subtypes of Pancreatic adenocarcinoma (PDAC) with prognostic and theragnostic implications have been described. These molecular subtypes were defined by...
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Article
Open AccessDECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification
Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populat...
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Article
Open AccessThe murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression
Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from ...
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Article
Open AccessIntegrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting prognoses. These tumors are defined by recurrent mutations in the IDH genes and other genetic alterations including inactivat...
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Article
Open AccessDissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on histology and molecular profiling. Histology addresses inter-tumor and intra-tumor heterogeneity in MPM and describes three maj...
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Article
Open AccessDistinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying ep...
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Article
Extensive characterization of sphere models established from colorectal cancer cell lines
Links between cancer and stem cells have been proposed for many years. As the cancer stem cell (CSC) theory became widely studied, new methods were developed to culture and expand cancer cells with conserved d...
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Article
Development of two screening duplex PCR assays for genetically modified organism quantification using multiplex real-time PCR master mixes
Since 2001, the traceability and labelling of genetically modified organism (GMO) food and feed derived products are obligatory in the European Union. Genetically modified organisms (GMO) are commonly detected...
