218 Result(s)

Article

Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study

Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...

Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai… in BMC Cancer (2024)

Article

Neoadjuvant programmed cell death 1 blockade combined with chemotherapy for locally advanced head and neck squamous cell carcinoma

Anatomical structures and organ preservation concepts of the head and neck are important for patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC). Neoadjuvant chemotherapy has been a...

** Han, Faya Liang, Pan Song, Taowei Wu, Yangyang Li… in Holistic Integrative Oncology (2024)

Article

N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance

Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, ...

Ming-Jian Ma, Yin-Hao Shi, Zhi-De Liu, Ying-Qin Zhu, Guang-Yin Zhao… in Oncogene (2024)

Article

A miRNA-disease association prediction model based on tree-path global feature extraction and fully connected artificial neural network with multi-head self-attention mechanism

MicroRNAs (miRNAs) emerge in various organisms, ranging from viruses to humans, and play crucial regulatory roles within cells, participating in a variety of biological processes. In numerous prediction method...

Hou Biyu, Li Mengshan, Hou Yuxin, Zeng Ming, Wang Nan, Guan Lixin in BMC Cancer (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Outcomes of patients in nasopharyngeal adenoid cystic carcinoma in the IMRT era: a single-center experience

Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with special biological features. Controversies exist regarding the treatment approach and prognostic factors in the IMRT era. This study aim...

Wen-Bin Wu, Wu-Lin Cai, Ye-Hao Zou, Rui You, You-** Liu, Zhao-Di Yuan… in BMC Cancer (2024)

Article

Pathogenic variants in human DNA damage repair genes mostly arose in recent human history

Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affec...

Bo** Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia **ao… in BMC Cancer (2024)

Article

Comprehensive evaluation of serum hepatic proteins in predicting prognosis among cancer patients with cachexia: an observational cohort study

Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these thr...

Jia-**n Huang, ** Zhang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li… in BMC Cancer (2024)

Article

Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential

MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit (TH). DLBCL-MYC/BCL2-DH/TH are largely germin...

Chunye Zhang, Ellen Stelloo, Sharon Barrans, Francesco Cucco, Dan Jiang… in Leukemia (2024)

Article

Combined score based on plasma fibrinogen and platelet-lymphocyte ratio as a prognostic biomarker in esophageal squamous cell carcinoma

Increasing evidence has showed that inflammatory biomarkers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and fibrinogen can be used as predictors in the prognosis of esop...

Yuchong Yang, Hui Tan, Yao Lu, Jipeng Mei, Mengqi Zhang, Ming Bai, **a Wang… in BMC Cancer (2024)

Article

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone ...

Yujia Huang, Ming Tang, Zhiyi Hu, Bailian Cai, Guofang Chen, Lijun Jiang… in Oncogenesis (2024)

Article

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibr...

Ji Jia, **ng-an Zhao, Si-ming Tao, Jun-wen Wang… in European Journal of Medical Research (2023)

Article

Comparison of efficacy and safety between PD-1 inhibitors and PD-L1 inhibitors plus platinum-etoposide as first-line treatment for extensive-stage small-cell lung cancer: a multicenter, real-world analysis

Immunotherapy in combination with platinum-etoposide (EP) chemotherapy has been approved as a first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). However, real-world (RW) data regarding ...

Yanrong Wang, Lingling Li, Jia Hu, Yan Zhao, Huan Yan, Ming Gao, Xuejiao Yang… in BMC Cancer (2023)

Article

Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients

Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

Kong-Ying Lin, Qing-**g Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-** Zhang… in BMC Cancer (2023)

Article

Regular gastroscopy and colonoscopy during the evaluation of urachal cancer: do we really need them?

Urachal cancer is similar to gastrointestinal adenocarcinoma in histology, and gastroscopy/colonoscopy is often administered during perioperative evaluation. However, gastroscopy and colonoscopy have correspon...

Ming-rui Luo, Tao-nong Cai, Jiang-li Lu, Zhen-hua Liu, Sheng-jie Guo… in BMC Cancer (2023)

Article

A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation

The primary objective of this study was to evaluate the efficacy and safety of pulsed field ablation in individuals diagnosed with atrial fibrillation.

Ming Yang, Peng-yu Wang, Ying-lu Hao, Mei Liang… in European Journal of Medical Research (2023)

Article

Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

Meng-Yao Wang, Bin Qi, Fang Wang, Zhi-Rui Lin, Ming-Yi Li, Wen-**g Yin… in Oncogenesis (2023)

Article

Identification of a potential bioinformatics-based biomarker in keloids and its correlation with immune infiltration

Keloid formation is a pathological consequence resulting from cutaneous irritation and injury, primarily attributed to excessive collagen matrix deposition and fibrous tissue proliferation. Chronic inflammatio...

Zihan Li, Chuwei Zhang, Qingrong Zhang, Yipeng Dong… in European Journal of Medical Research (2023)