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Article
Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Article
Open AccessImpact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking Han Chinese women
Smoking tobacco is the major risk factor for develo** lung cancer. However, most Han Chinese women with lung cancer are nonsmokers. Chinese cooking methods usually generate various carcinogens in fumes that ...
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Chapter
Design and Data Analysis of Multiregional Clinical Trials (MRCTs)—Theory and Practice
In recent years, has become strategy to develop new medicines. Implementing the same protocol to include subjects from many geographical regions around the world, MRCTs could speed up the patient enrollmen...
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Article
Open AccessPrediction of plasma efavirenz concentrations among HIV-positive patients taking efavirenz-containing combination antiretroviral therapy
We investigated the predictors of plasma mid-dose concentrations (C12) of efavirenz by enrolling 456 HIV-positive patients who had received 2 nucleos(t)ide reverse-transcriptase inhibitors plus efavirenz (600 ...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Chapter and Conference Paper
Assessing Benefit and Consistency of Treatment Effect Under a Discrete Random Effects Model in Multiregional Clinical Trials
The traditionally uniform treatment effect assumption may be inappropriate in an multiregional clinical trial (MRCT) because of the impact on the drug effect due to regional differences. Lan and and Pinheiro (...
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Article
Quality of life changes in patients undergoing treatment for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. One of the primary treatment goals for incurable advanced cases is to prolong quality of life (QoL). Thus, to deter...
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Article
Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)
We previously carried out a multi-stage genome-wide association study (GWAS) on lung cancer among never smokers in the Female Lung Cancer Consortium in Asia (FLCCA) (6,609 cases, 7,457 controls) that identifie...
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Article
Risk factors for primary lung cancer among never smokers by gender in a matched case–control study
Lung cancers that occur in never smokers differ from those that occur in smokers. We performed an analysis of potential epidemiological risk factors for lung cancer among never smokers.
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Chapter and Conference Paper
Use of Random Effect Models in the Design and Analysis of Multi-regional Clinical Trials
In recent years, global collaboration has become a commonly used strategy for new drug development. To accelerate the development process and shorten the approval time, the design of multi-regional clinical tr...
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Article
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously rep...
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Article
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10−12); howev...
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Article
Role of topography in the behavior of the matric suction of unsaturated fill slopes
This paper presents the result of a field study on the influence of topography on the distribution of the matric suction of the soil in unsaturated slopes subjected to rainfall. The matric suction was measured...
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Article
Bridging Diversity
In recent years, global collaboration has led to a new strategy for drug development. However, clinical outcomes may be influenced by geographic variations in efficacy and safety; significant ethnic difference...
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Article
Statistical Validation of Traditional Chinese Diagnostic Procedures
In recent years, the modernization of traditional Chinese medicine (TCM) for treatment of patients with critical and life-threatening diseases has attracted much attention in the pharmaceutical industry. The m...
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Article
A Two-Stage Design for Drug Screening Trials Based on Continuous Endpoints
Pharmaceutical development is a risky, complex, costly, and time-consuming endeavor. More than half of development duration is spent in clinical trials. Despite the large number of potential candidates availab...
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Article
A program for monotonizing two empirical bayes estimators in binomial and hypergeometric data distributions
