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Article
Open AccessTranscriptomic profiling of dynamic alternative splicing during the early response to Ralstonia solanacearum infection in tobacco roots
The pathogenic bacterium, Ralstonia solanacearum, causes bacterial wilt disease in many crops, which leads to significant yield losses worldwide. Although genes associated with resistance to this pathogen have be...
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Article
A Novel Pancreatic Cancer Hypoxia Status Related Gene Signature for Prognosis and Therapeutic Responses
Pancreatic cancer (PAC) is a highly fatal and aggressive type of cancer. Hypoxia is a common feature of PAC. The aim of this study was to develop a hypoxia status-related prognostic model for predicting the su...
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Article
Artificial Immune System of Secure Face Recognition Against Adversarial Attacks
Deep learning-based face recognition models are vulnerable to adversarial attacks. In contrast to general noises, the presence of imperceptible adversarial noises can lead to catastrophic errors in deep face r...
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Article
Open-Set Single-Domain Generalization for Robust Face Anti-Spoofing
Face anti-spoofing is a critical component of face recognition technology. However, it suffers from poor generalizability for cross-scenario target domains due to the simultaneous presence of unseen domains an...
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Article
Robust optimal subsampling based on weighted asymmetric least squares
With the development of contemporary science, a large amount of generated data includes heterogeneity and outliers in the response and/or covariates. Furthermore, subsampling is an effective method to overcome...
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Article
Open AccessWSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination
Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims t...
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Article
Open AccessExploration and validation of a combined Hypoxia and m6A/m5C/m1A regulated gene signature for prognosis prediction of liver cancer
It is widely acknowledged that hypoxia and m6A/m5C/m1A RNA modifications promote the occurrence and development of tumors by regulating the tumor microenvironment. This study aimed to establish a novel liver c...
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Article
Open AccessComprehensive analysis of cancer of unknown primary and recommendation of a histological and immunohistochemical diagnostic strategy from China
Previous studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical evaluation of different IHC markers, so this study aimed to evaluate chara...
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Article
Landslide displacement prediction based on spatio-temporal association rule mining between target case and similar cases
The displacement response of landslides to external influencing factors varies according to different creep stages. However, most traditional models ignored this variation and yielded low prediction accuracy e...
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Article
Open AccessDecoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score
Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting the metastatic potential of non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments fo...
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Article
Open AccessPrediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
Melanoma is the deadliest form of skin tumor, and G protein-coupled receptors (GPCRs) play crucial roles in its carcinogenesis. Furthermore, the tumor microenvironment (TME) affects the overall survival (OS) a...
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Article
Open AccessNovel prognostic gene signature for pancreatic ductal adenocarcinoma based on hypoxia
Currently, there is lack of marker to accurately assess the prognosis of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC). This study aims to establish a hypoxia-related risk scoring model that ...
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Article
Open AccessDeep learning to automatically evaluate HER2 gene amplification status from fluorescence in situ hybridization images
Human epidermal growth factor receptor 2 (HER2) gene amplification helps identify breast cancer patients who may respond to targeted anti-HER2 therapy. This study aims to develop an automated method for quanti...
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Article
Open AccessSome properties of branching processes with random control functions and affected by viral infectivity in random environments
In this paper, a model of branching processes with random control functions and affected by viral infectivity in independent and identically distributed random environments is established, and the Markov prope...
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Article
Open AccessGenome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in abiotic stress and flavonol biosynthesis in Nicotiana tabacum
Uridine disphosphate (UDP) glycosyltransferases (UGTs) act upon a huge variety of highly diverse and complex substrates, such as phytohormones and specialized metabolites, to regulate plant growth, development...
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Article
Phytoplanktonic biogeography in the subtropical coastal waters, East China Sea along intensive anthropogenic stresses: roles of environmental versus spatial factors
Understanding the relative roles of local environmental effects and spatial effects on phytoplankton community is of essential importance to study the biogeography of them at regional scale. However, the deter...
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Article
Open AccessA comparative analysis of diagnostic values of high-frequency ultrasound and fiberoptic ductoscopy for pathologic nipple discharge
This study aimed to compare the diagnostic accuracy of high-frequency ultrasound (HFUS) and fiberoptic ductoscopy (FDS) for pathologic nipple discharge (PND).
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Article
Halomonas **caotanensis sp. nov., isolated from the Pamir Plateau degrading polycyclic aromatic hydrocarbon
A Gram-strain-negative, rod-shaped, aerobic bacterium, designated strain TRM 85114T, was isolated from the **caotan wetland in the Pamir Plateau of China. This strain grew optimally at 30 °C and pH 6.0 in the pr...
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Article
Towards Interpretable Defense Against Adversarial Attacks via Causal Inference
Deep learning-based models are vulnerable to adversarial attacks. Defense against adversarial attacks is essential for sensitive and safety-critical scenarios. However, deep learning methods still lack effecti...
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Article
KCNQ1OT1 affects cell proliferation, invasion, and migration through a miR-34a / Notch3 axis in breast cancer
Breast cancer (BC) accounts for a significant share of cancer-related deaths worldwide. Ongoing investigations have shown that long non-coding RNAs (lncRNAs) drive BC progression but their underlying mechanism...
