10 Result(s)
within
Miia Turpeinen
English
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Article
Open AccessReporting of costs and economic impacts in randomized trials of de-implementation interventions for low-value care: a systematic sco** review
De-implementation of low-value care can increase health care sustainability. We evaluated the reporting of direct costs of de-implementation and subsequent change (increase or decrease) in health care costs in...
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Article
Open AccessInvestigating errors in medical imaging: medical malpractice cases in Finland
The objectives of the study were to survey patient injury claims concerning medical imaging in Finland in 1991–2017, and to investigate the nature of the incidents, the number of claims, the reasons for the cl...
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Article
CYP-associated drug–drug interactions: A mission accomplished?
On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between 2007 and 2016 were substrates, inhibitors or inducers of CYP e...
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Article
Open AccessInhibition and induction of CYP enzymes in humans: an update
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies and toxic compounds in the environ...
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Protocol
Consideration of Metabolism in In Vitro Cellular Systems
Toxicokinetic (TK) behavior of most chemicals is determined to a large extent by metabolism (xenobiotic-metabolizing enzymes). If metabolic processes were to be measured in in vitro cellular systems, it is of ...
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Article
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction
We assessed possible drug interactions of tramadol given concomitantly with the potent CYP2B6 inhibitor ticlopidine, alone or together with the potent CYP3A4 and P-glycoprotein inhibitor itraconazole.
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Article
In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development
Although clinical drug trials are indispensable in providing an appropriate background for dosage recommendations, they can provide mechanistic pharmacokinetic information only indirectly with the help of cert...
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Article
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
We investigated the elimination routes for the 200 drugs that are sold most often by prescription count in the United States. The majority (78%) of the hepatically cleared drugs were found to be subject to oxi...
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Article
Inhibition and induction of human cytochrome P450 enzymes: current status
Variability of drug metabolism, especially that of the most important phase I enzymes or cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of pharmacology and toxicology, in drug...
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Article
Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors
To characterise in detail the patterns of expression and functional activities of CYP and efflux pump genes in Caco-2 cells stably transfected with human Pregnane X Receptor or murine Constitutive Androstane R...
