17 Result(s)
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Article
Open AccessTranscriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway...
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Open AccessStudy protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer
Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...
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Article
Menstrual cycle characteristics and steroid hormone, prolactin, and growth factor levels in premenopausal women
Menstrual cycle characteristics are markers of endocrine milieu. However, associations between age at menarche and adulthood sex steroid hormone levels have been inconsistent, and data on menstrual characteris...
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Open AccessCirculating resistin levels and risk of multiple myeloma in three prospective cohorts
Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case–control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, th...
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Circulating levels of obesity-related markers and risk of renal cell carcinoma in the PLCO cancer screening trial
Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormone...
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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Elevated plasma levels of branched chain amino acids detected prior to pancreatic cancer diagnosis may result from whole body tissue breakdown occurring during the early stages of this disease.
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Association of C-peptide and leptin with prostate cancer incidence in the Health Professionals Follow-up Study
Hyperinsulinemia is hypothesized to influence prostate cancer risk. Thus, we evaluated the association of circulating C-peptide, which is a marker of insulin secretion, and leptin, which is secreted in respons...
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Type 2 diabetes and the risk of mortality among patients with prostate cancer
The aim of this study was to determine whether type 2 diabetes is associated with the incidence of prostate cancer mortality and all-cause mortality.
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Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada)
Mammographic breast density (BD) is associated with increased risk of breast cancer. This study asks which circulating metabolic and reproductive biomarkers are associated with BD, particularly dense breast ar...
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Article
Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer
Androgens are known to play an important protective role on colorectal carcinogenesis, and thus the objective of this study was to determine whether androgen deprivation therapy (ADT) is associated with an inc...
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Article
Racial variation in vitamin D cord blood concentration in white and black male neonates
The aim of this study is to evaluate racial variation in umbilical cord blood concentration of vitamin D and to explore its correlation with markers of the insulin-like growth factor axis (IGFs) and sex steroi...
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Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates
To evaluate whether there is racial variation in venous umbilical cord blood concentrations of sex steroid hormones and the insulin-like growth factor (IGF) axis between female African-American and white neona...
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Article
Metabolic syndrome components and colorectal adenoma in the CLUE II cohort
Metabolic syndrome components have been associated with colorectal cancer in several studies; however, evidence for colorectal adenomas is limited. Thus, we evaluated the association between markers of the met...
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Hormonal profile of diabetic men and the potential link to prostate cancer
Previous studies suggest men with diabetes may be at reduced risk for prostate cancer as compared to men without diabetes. To investigate potential biological mechanisms, hormonal profiles of diabetic men and...
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Article
Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
Objective The insulin-like growth factor (IGF) axis is thought to contribute to the growth and progression of prostate cancer. Some prospective studies support a direct association between IGF-1 and prostate canc...
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Insulin-like growth factors and neoplasia
Insulin-like growth factor 1 (IGF1) has characteristics of both a circulating hormone and a tissue growth factor.
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Challenges to cancer control by screening
Population-based screening seems to be a common-sense strategy for controlling cancer, but recent reports have raised controversy concerning the benefits of common screening procedures. Intense efforts to deve...
