19 Result(s)

Article

Three-month life expectancy as inclusion criterion for clinical trials in advanced pancreatic cancer: is it really a valid tool for patient selection?

To analyze the 3-month life expectancy rate in pancreatic cancer (PC) patients treated within prospective trials from the German AIO study group.

Lena Weiss, Volker Heinemann, Laura E. Fischer… in Clinical and Translational Oncology (2024)

Article

A Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich

With the rising importance of precision oncology in biliary tract cancer (BTC), the aim of this retrospective single-center analysis was to describe the clinical and molecular characteristics of patients with ...

Danmei Zhang, Klara Dorman, Kathrin Heinrich, Lena Weiss… in Targeted Oncology (2023)

Article

Direct detection of photo-induced reactions by IR: from Brook rearrangement to photo-catalysis

In situ IR detection of photoreactions induced by the light of LEDs at appropriate wavelengths provides a simple, cost-effective, and versatile method to get insight into mechanistic details. In particular, co...

Gabriel Glotz, Sabrina Püschmann, Michael Haas… in Photochemical & Photobiological Sciences (2023)

Article

TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer

Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased malignancy. Its effect on gemcitabine resistance in pancreatic ductal adenocarcinoma (PD...

Michael Guenther, Sai Agash Surendran, Michael Haas… in British Journal of Cancer (2023)

Article

Serum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers

Novel biomarkers to better predict outcome and select the best therapeutic strategy for the individual patient are necessary for pancreatic ductal adenocarcinoma (PDAC).

Klara Dorman, Miriam Gerckens… in Journal of Cancer Research and Clinical On… (2023)

Article

Precision Oncology in Pancreatic Cancer: Experiences and Challenges of the CCCMunich^LMU Molecular Tumor Board

In pancreatic cancer, systemic treatment options in addition to chemotherapy remain scarce, and so far only a small proportion of patients benefit from targeted therapies.

Klara Dorman, Danmei Zhang, Kathrin Heinrich, Laurens Reeh, Lena Weiss… in Targeted Oncology (2023)

Article

Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation

FIP200 is an essential autophagy gene implicated in the regulation of postnatal neural progenitor/stem cells (NSCs). However, the contribution of FIP200’s canonical-autophagy function and its non-canonical fun...

Hang Liu, Chenran Wang, Fei Yi, Syn Yeo, Michael Haas, **n Tang… in Scientific Reports (2021)

Article

Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response

Laura Poillet-Perez, Daniel W. Sharp, Yang Yang, Saurabh V. Laddha… in Nature Cancer (2021)

Article

Correction: Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study

Michael Guenther, Michael Haas, Volker Heinemann… in British Journal of Cancer (2021)

Article

Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study

Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced p...

Michael Guenther, Michael Haas, Volker Heinemann… in British Journal of Cancer (2020)

Article

Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation

The mechanistic target of rapamycin complex 1 (mTORC1) is important in the development and progression of many cancers. Targeted cancer therapy using mTORC1 inhibitors is used for treatment of cancers; however...

Fuchun Yang, Shaogang Sun, Chenran Wang, Michael Haas, Syn Yeo… in British Journal of Cancer (2020)

Article

Molecular cobalt corrole complex for the heterogeneous electrocatalytic reduction of carbon dioxide

Electrochemical conversion of CO₂ to alcohols is one of the most challenging methods of conversion and storage of electrical energy in the form of high-energy fuels. The challenge lies in the catalyst design to e...

Sabrina Gonglach, Shounik Paul, Michael Haas, Felix Pillwein… in Nature Communications (2019)

Chapter

Global Mass Society

Economic globalization has resulted in corporations, unaccountable to states, making key decisions within an otherwise anarchic world order, rendering normal democratic functioning almost impossible. Global gr...

Michael Haas in Why Democracies Flounder and Fail (2019)

Article

Synthesis and characterization of meso-substituted A₂B corroles with extended π-electronic structure

We report the chemical synthesis and characterization of the stable 5,15-bis(pentafluorophenyl)-10-(trimethylsilylethynyl)corrole which serves as a precursor for the subsequent in situ sila-Sonogashira-cross-c...

Michael Haas, Sabrina Gonglach… in Monatshefte für Chemie - Chemical Monthly (2018)

Article

Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors....

Sibylle Baechmann, Steffen Ormanns, Michael Haas, Stephan Kruger, Anna Remold… in BMC Cancer (2017)

Article

Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer

Mutations in the KRAS gene can be detected in about 70–90% of pancreatic cancer (PC) cases. Whether these mutations have a prognostic or predictive value remains elusive. Furthermore, the clinical relevance of...

Michael Haas, Steffen Ormanns, Sibylle Baechmann, Anna Remold… in British Journal of Cancer (2017)

Article

Predictors of elevational biodiversity gradients change from single taxa to the multi-taxa community level

The factors determining gradients of biodiversity are a fundamental yet unresolved topic in ecology. While diversity gradients have been analysed for numerous single taxa, progress towards general explanatory ...

Marcell K. Peters, Andreas Hemp, Tim Appelhans, Christina Behler… in Nature Communications (2016)

Article

Impact of SPARC expression on outcome in patients with advanced pancreatic cancer not receiving nab-paclitaxel: a pooled analysis from prospective clinical and translational trials

Conflicting results on the role of secreted protein acidic and rich in cysteins (SPARC) expression have been reported in resected pancreatic ductal adenocarcinoma (PDAC), and its prognostic and/or predictive r...

Steffen Ormanns, Michael Haas, Sibylle Baechmann… in British Journal of Cancer (2016)

Article

pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104

The role of pERK, pAKT and p53 as biomarkers in patients with advanced pancreatic cancer has not yet been defined.

Steffen Ormanns, Jens T Siveke, Volker Heinemann, Michael Haas, Bence Sipos… in BMC Cancer (2014)