Professionalization of Foreign Policy
Transformation of Operational Code Analysis
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Open AccessThree-month life expectancy as inclusion criterion for clinical trials in advanced pancreatic cancer: is it really a valid tool for patient selection?
To analyze the 3-month life expectancy rate in pancreatic cancer (PC) patients treated within prospective trials from the German AIO study group.
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A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC)
Dickkopf-related protein 1 (DKK1) is a Wingless-related integrate site (Wnt) signaling modulator that is upregulated in prostate cancers (PCa) with low androgen receptor expression. DKN-01, an IgG4 that neutra...
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Open AccessA Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich
With the rising importance of precision oncology in biliary tract cancer (BTC), the aim of this retrospective single-center analysis was to describe the clinical and molecular characteristics of patients with ...
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Open AccessDirect detection of photo-induced reactions by IR: from Brook rearrangement to photo-catalysis
In situ IR detection of photoreactions induced by the light of LEDs at appropriate wavelengths provides a simple, cost-effective, and versatile method to get insight into mechanistic details. In particular, co...
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Open AccessTPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased malignancy. Its effect on gemcitabine resistance in pancreatic ductal adenocarcinoma (PD...
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Open AccessSerum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers
Novel biomarkers to better predict outcome and select the best therapeutic strategy for the individual patient are necessary for pancreatic ductal adenocarcinoma (PDAC).
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Open AccessPrecision Oncology in Pancreatic Cancer: Experiences and Challenges of the CCCMunichLMU Molecular Tumor Board
In pancreatic cancer, systemic treatment options in addition to chemotherapy remain scarce, and so far only a small proportion of patients benefit from targeted therapies.
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Chapter
Implications for Foreign Policy Research
The final chapter summarizes the main contribution of the book—namely, to provide a method by which foreign policy decision-makers can require their advisers to rate all possible options and then input their j...
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Chapter
Omnipresence of Codes
Part II of the book is developed into operational code research, notably this chapter and Chapter 5. During the Cold War, fear of nuclear war prompted much of the pre-th...
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Parameters of Decision-Making and Options Analysis
Part III identifies how to professionalize foreign policy decision-making in this chapter and Chapters 7–10 though Options Ana...
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Book
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Chapter
American Policies Toward North Korea
North Korea is now a nuclear power, thanks to blunder after blunder in American foreign policy, most notably a key decision by President Barack Obama in 2013. The chapter begins with the background in earlier ...
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Chapter
Early Approaches to the Study of Foreign Policy
Part I of the book is developed into the historiography of foreign policy analysis in this chapter and Chapter 2, with a test of theories in Chapter 3
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Quantifying Alternative Pre-Theories
Rather than allowing the field of foreign policy analysis to linger, an effort is undertaken to pool almost all concepts about decision-making and rate their importance across a database of 32 decisions, domes...
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Developments and Problems in Operational Code Research
The pioneering work of Stephen Walker, with many collaborators is provided in detail, giving rise to many insights about decision-making. Social psychological approaches strengthened the analysis, which in due...
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American Policies Toward Cambodia
This chapter and Chapters 8 and 9 demonstrate how Options Analysis can be applied to three foreign policy decisions made by Am...
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Chapter
American Policies Toward Ukraine
Ukraine occupies the longest chapter in the book, providing historical context for a war that began in the last week of February 2022. Although Western intelligence predicted a quick Russian takeover of the co...
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Chapter
Pre-Theories of Decision-Making
During World War II, social science was applied as a tool to fight the war, so afterward there was a flurry of activity in foreign policy analysis, trying to apply social psychology and sociology to better und...
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Article
Open AccessNon-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation
FIP200 is an essential autophagy gene implicated in the regulation of postnatal neural progenitor/stem cells (NSCs). However, the contribution of FIP200’s canonical-autophagy function and its non-canonical fun...
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Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
