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Article
Enhanced antitumor activity of irofulven in combination with irinotecan in pediatric solid tumor xenograft models
Irofulven, a novel chemotherapeutic agent with a broad spectrum of activity, is effective against preclinical models of pediatric tumors. The cytotoxic activity of irofulven is augmented when combined with age...
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Protocol
Studying DNATopoisomerase I-Targeted Drugs In the Yeast
The budding yeast Saccharomyces cerevisiae has been a valuable model in establishing eukaryotic DNA topoisomerase I as the cellular target of specific antineoplastic agents, including camptothecin (1–3), aclacino...
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Article
Pharmacokinetics of paclitaxel in an anephric patient
Purpose: To assess the pharmacokinetics of paclitaxel for recurrent Wilms' tumor in an anephric pediatric patient receiving hemodialysis. Methods: Paclitaxel was administered at a dose of 250 mg/m2 and 350 mg/m2