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Article
Chagas Disease Epidemiology in Central America: an Update
Chagas disease is endemic to all seven Central American countries, where 12% of the population lives in areas where the disease is a risk. While neglect is a pervasive characteristic of Chagas disease in gener...
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Article
Chagas Disease in Central America: Recent Findings and Current Challenges in Vector Ecology and Control
In Central America, most new human Trypanosoma cruzi infections (Chagas disease) are vector-borne, primarily by native vector species. Given the importance of vector control in reducing Chagas disease incidence, ...
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Article
Healthcare Disparities in Outcomes of a Metropolitan Congenital Heart Surgery Center: The Effect of Clinical and Socioeconomic Factors
The purpose of this study is to identify the impact of demographic, socioeconomic, and clinical factors on congenital heart surgery outcomes.
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Article
Open AccessQuantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases
Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need to develop these tools to inform policy to achieve the...
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Article
Open AccessBroad patterns in domestic vector-borne Trypanosoma cruzi transmission dynamics: synanthropic animals and vector control
Chagas disease (caused by Trypanosoma cruzi) is the most important neglected tropical disease (NTD) in Latin America, infecting an estimated 5.7 million people in the 21 countries where it is endemic. It is one o...
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Article
Isolation, characterization and cross-species amplification of new microsatellite markers for three opossum species of the Didelphidae family
The American opossums from the Didelphidae family (Order: Didelphimorphia) are on the IUCN Red List, and their threatened status varies from extinct to data deficient. Although microsatellites have already bee...
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Article
Enhanced antitumor activity of irofulven in combination with irinotecan in pediatric solid tumor xenograft models
Irofulven, a novel chemotherapeutic agent with a broad spectrum of activity, is effective against preclinical models of pediatric tumors. The cytotoxic activity of irofulven is augmented when combined with age...
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Chapter
Experimental Therapeutics and Preclinical Models