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Article
Genetics of mouse behavioral and peripheral neural responses to sucrose
Mice of the C57BL/6ByJ (B6) strain have higher consumption of sucrose, and stronger peripheral neural responses to it, than do mice of the 129P3/J (129) strain. To identify quantitative trait loci (QTLs) respo...
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Article
Genetic controls of Tas1r3-independent sucrose consumption in mice
We have previously used crosses between C57BL/6ByJ (B6) and 129P3/J (129) inbred strains to map a quantitative trait locus (QTL) on mouse chromosome (Chr) 4 that affects behavioral and neural responses to sucr...
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Article
Open AccessCALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells
Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release...
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Article
Open AccessLow-calcium diet prevents fructose-induced hyperinsulinemia and ameliorates the response to glucose load in rats
Consuming a fructose-rich diet leads to hyperinsulinemia, impaired glucose tolerance, and insulin resistance. In humans, the consumption of high levels of refined sugars often coincides with a diet containing ...
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Article
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
The voltage-gated ion channel CALHM1 is vital to taste-stimuli-evoked ATP release from sweet-, bitter- and umami-sensing taste bud cells in mice, but does not seem relevant to the recognition of sour and salty...
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Article
Open AccessT1R3: A human calcium taste receptor
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by...
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Article
Open AccessReduced body weight is a common effect of gene knockout in mice
During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight. To determine whether this was a general feature of gene kno...
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Article
Genetic loci affecting body weight and fatness in a C57BL/6J × PWK/PhJ mouse intercross
To determine the genetic variation that contributes to body composition in the mouse, we interbred a wild-derived strain (PWK/PhJ; PWK) with a common laboratory strain (C57BL/6J; B6). The parental, F1, and F2 mic...
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Article
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
To identify the gene or genes on mouse Chromosome 9 that contribute to strain differences in fatness, we conducted an expanded map** analysis to better define the region where suggestive linkage was found, u...
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Article
Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice
To understand how genotype influences fat patterning and obesity, we conducted an autosomal genome scan using male and female F2 hybrids between the C57BL/6ByJ and 129P3/J parental mouse strains. Mice were studie...
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Article
Loci on Chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
Mice have proved to be a powerful model organism for understanding obesity in humans. Single gene mutants and genetically modified mice have been used to identify obesity genes, and the discovery of loci for p...
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Article
Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/HlJ, LP/J, NOD/LtJ, NZB/BlNJ, P/J, PL/J, RBF/DnJ, RF/J, RII...
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Article
Voluntary Consumption of NaCl, KCl, CaCl2, and NH4Cl Solutions by 28 Mouse Strains
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/H1J, LP/J, NOD/LtJ, NZB/B1NJ, P/J, PL/J, RBF/DnJ, RF/J, RII...
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Article
Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4
The subtelomeric region of mouse chromosome (Chr) 4 harbors loci with effects on behavior, development, and disease susceptibility. Regions near the telomeres are more difficult to map and characterize than ot...
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Article
High-resolution genetic map** of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4. A putative sweet taste receptor, T1R1, has been recently cloned, and the g...
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Article
Voluntary Sodium Chloride Consumption by Mice: Differences Among Five Inbred Strains
We examined voluntary NaCl intakes of five mouse strains: NZB/B1NJ, SM/J, 129/J, C57BL/6ByJ, and CBA/J. Using two-bottle tests with water as one choice, the mice were offered series of progressively increasing...
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Article
Sucrose consumption in mice: Major influence of two genetic Loci affecting peripheral sensory responses
Individual variability in sucrose consumption is prominent in humans and other species. To investigate the genetic contribution to this complex behavior, we conducted behavioral, electrophysiological, and gene...
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Article
Heritable Variation in Food Preferences and Their Contribution to Obesity
What an animal chooses to eat can either induce or retard the development of obesity; this review summarizes what is known about the genetic determinants of nutrient selection and its impact on obesity in huma...
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Article
A peripheral locus for amphetamine anorexia
The anorexic action of amphetamine is thought to be mediated by central dopaminergic and noradrenergic neurotransmitter systems1–4. However, some of its sympathomimetic effects can be attenuated by denervation5 o...
