-
Article
Genetics of mouse behavioral and peripheral neural responses to sucrose
Mice of the C57BL/6ByJ (B6) strain have higher consumption of sucrose, and stronger peripheral neural responses to it, than do mice of the 129P3/J (129) strain. To identify quantitative trait loci (QTLs) respo...
-
Article
Genetic controls of Tas1r3-independent sucrose consumption in mice
We have previously used crosses between C57BL/6ByJ (B6) and 129P3/J (129) inbred strains to map a quantitative trait locus (QTL) on mouse chromosome (Chr) 4 that affects behavioral and neural responses to sucr...
-
Chapter
COVID-19-Associated Loss of Taste and Smell and the Implications for Sensory Nutrition
The loss of taste and smell caused by COVID-19 is a pandemic that may outlast the virus and have long-term effects on nutrition and human health. While the loss of smell after a viral illness is a rare side ef...
-
Article
Open AccessBivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste
Human perception of bitter substances is partially genetically determined. Previously we discovered a single nucleotide polymorphism (SNP) within the cluster of bitter taste receptor genes on chromosome 12 tha...
-
Article
Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2
To fine map a mouse QTL for lean body mass (Burly1), we used information from intercross, backcross, consomic, and congenic mice derived from the C57BL/6ByJ (host) and 129P3/J (donor) strains. The results from th...
-
Article
Open AccessGenetic analysis of impaired trimethylamine metabolism using whole exome sequencing
Trimethylaminuria (TMAU) is a genetic disorder whereby people cannot convert trimethylamine (TMA) to its oxidized form (TMAO), a process that requires the liver enzyme FMO3. Loss-of-function variants in the FMO3 ...
-
Article
Open AccessVariation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults
The nonnutritive sweetener (NNS) acesulfame potassium (Ace-K) elicits a bitter off-taste that varies among adults due to polymorphisms in a bitter taste receptor gene. Whether polymorphisms affect liking for A...
-
Article
The development of sweet taste: From biology to hedonics
From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day—a troubling statistic, given that food preferences are established earl...
-
Article
Open AccessChildren’s perceptions about medicines: individual differences and taste
Bitter taste receptors are genetically diverse, so children likely vary in sensitivity to the “bad” taste of some pediatric formulations. Based on prior results that variation in a bitter taste receptor gene, TAS...
-
Article
Open AccessHeritable differences in chemosensory ability among humans
The combined senses of taste, smell and the common chemical sense merge to form what we call ‘flavor.’ People show marked differences in their ability to detect many flavors, and in this paper, we review the r...
-
Article
Open AccessAge modifies the genotype-phenotype relationship for the bitter receptor TAS2R38
The purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human bitter taste perception.
-
Article
Open AccessReduced body weight is a common effect of gene knockout in mice
During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight. To determine whether this was a general feature of gene kno...
-
Article
Genetic loci affecting body weight and fatness in a C57BL/6J × PWK/PhJ mouse intercross
To determine the genetic variation that contributes to body composition in the mouse, we interbred a wild-derived strain (PWK/PhJ; PWK) with a common laboratory strain (C57BL/6J; B6). The parental, F1, and F2 mic...
-
Article
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
To identify the gene or genes on mouse Chromosome 9 that contribute to strain differences in fatness, we conducted an expanded map** analysis to better define the region where suggestive linkage was found, u...
-
Article
Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice
To understand how genotype influences fat patterning and obesity, we conducted an autosomal genome scan using male and female F2 hybrids between the C57BL/6ByJ and 129P3/J parental mouse strains. Mice were studie...
-
Article
Open AccessThe Human Sweet Tooth
Humans love the taste of sugar and the word "sweet" is used to describe not only this basic taste quality but also something that is desirable or pleasurable, e.g., la dolce vita. Although sugar or sweetened food...
-
Article
Loci on Chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
Mice have proved to be a powerful model organism for understanding obesity in humans. Single gene mutants and genetically modified mice have been used to identify obesity genes, and the discovery of loci for p...
-
Article
Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/HlJ, LP/J, NOD/LtJ, NZB/BlNJ, P/J, PL/J, RBF/DnJ, RF/J, RII...
-
Article
Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4
The subtelomeric region of mouse chromosome (Chr) 4 harbors loci with effects on behavior, development, and disease susceptibility. Regions near the telomeres are more difficult to map and characterize than ot...
-
Article
A genome-wide scan suggests a locus on chromosome 1–23 contributes to normal variation in plasma cholesterol concentration
To identify genes that influence plasma cholesterol, triglyceride, and high-density and low-density lipoproteins concentrations we conducted a genome-wide scan using 354 polymorphic markers spaced at 10-cM in...
