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  1. No Access

    Article

    Fucoxanthin inhibits lipopolysaccharide-induced inflammation and oxidative stress by activating nuclear factor E2-related factor 2 via the phosphatidylinositol 3-kinase/AKT pathway in macrophages

    Anti-inflammatory and antioxidant effects of fucoxanthin (FCX), a xanthophyll carotenoid, have been suggested. However, underlying mechanisms are elusive. The objective of this study was to elucidate the mecha...

    Mi-Bo Kim, Hyunju Kang, Yang Li, Young-Ki Park… in European Journal of Nutrition (2021)

  2. No Access

    Article

    High hydrostatic pressure extract of Siegesbeckia orientalis inhibits adipogenesis through the activation of the Wnt/β-catenin signaling pathway

    St. Paul’s Wort (Siegesbeckia orientalis L.) confers anti-oxidative, anti-inflammatory, anti-allergic, anti-infertility, and immunosuppressive properties. Here, we elucidated whether high hydrostatic pressure ext...

    Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2020)

  3. No Access

    Article

    Hypoglycemic effect of whole grain diet in C57BL/KsJ-db/db mice by activating PI3K/Akt and AMPK pathways

    Type II diabetes mellitus (T2DM), characterized by abnormal blood glucose level, is a metabolic disease caused by pancreatic β-cell dysfunction and insulin resistance. Previous studies have reported that whole...

    Changhee Kim, Joonhyung Lee, Mi-Bo Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2019)

  4. No Access

    Article

    Inhibitory effect of vitamin C on intrinsic aging in human dermal fibroblasts and hairless mice

    Vitamin C significantly reduced senescence-associated β-galactosidase (SA-β-gal) activity, with both the suppression of cell-cycle inhibitors (p53, p21, p16, and pRb) and stimulation of cell-cycle activators (...

    Jae-Hong Jeong, Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2018)

  5. No Access

    Article

    The anti-photoaging and moisturizing effects of Bouea macrophylla extract in UVB-irradiated hairless mice

    Ultraviolet (UV) light, a main cause of photoaging, leads to collapse of skin structure, resulting in wrinkle formation and dehydration. The present study assessed the anti-photoaging and moisturizing effects of

    Yongin Cheong, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2018)

  6. No Access

    Article

    Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice

    Whole grain comprises starchy endosperm, germ, and bran tissues, which contain fibers, minerals, vitamins, and several phytochemicals. Whole grain cereal (WGC)-based food products supply beneficial nutrients (...

    Sein Lee, Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2018)

  7. No Access

    Article

    Fucosterol inhibits adipogenesis through the activation of AMPK and Wnt/β-catenin signaling pathways

    Fucosterol is a sterol constituent primarily derived from brown algae. Recently, the antiadipogenic effect of fucosterol has been reported; however, its molecular mechanism remains to be studied. Fucosterol ef...

    Youngwoo Song, Ga Hui Oh, Mi-Bo Kim, Jae-Kwan Hwang in Food Science and Biotechnology (2017)

  8. No Access

    Article

    Optimization of high hydrostatic pressure process for the extraction of kirenol from Siegesbeckia orientalis L. using response surface methodology

    High hydrostatic pressure (HHP) extraction method was optimized to maximize the extraction yield of kirenol from Siegesbeckia orientalis. Operating parameters such as extraction pressure (100–600 MPa), pressure h...

    Mi-Bo Kim, Ji-Eun Park, Seon Wook Woo, Sang-Bin Lim… in Food Science and Biotechnology (2014)

  9. No Access

    Article

    Fractionation and quantification of phenolic antioxidants from Saeunamu (Ostrya japonica)

    Saeunamu (Ostrya japonica), a natural plant in Jeju, was extracted and fractionated on a Sephadex LH-20 column, and their phenolic compounds and integral antioxidative capacity (IAC) were evaluated. Eight fractio...

    Jae-Sung Park, Mi-Bo Kim, Young-Hwan Ko, Sang-Bin Lim in Food Science and Biotechnology (2010)