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Article
Open AccessReplication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive. Current approaches to discover antiviral factors usu...
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Article
Open AccessSurface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model
Besides the many advantages of oral drug administration, challenges like premature drug degradation and limited bioavailability in the gastro-intestinal tract (GIT) remain. A prolonged residence time in the GI...
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Article
Open AccessSARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor
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Article
Open AccessSpike residue 403 affects binding of coronavirus spikes to human ACE2
The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, the cause of the COVID-19 pandemic. However, this bat virus was most likely unable to directly infect humans since its Spike (S) protein does not ...
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Article
Open AccessIFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression...
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Article
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
To avoid innate sensing and immune control, human immunodeficiency virus type 1 (HIV-1) has to prevent the accumulation of viral complementary DNA species. Here, we show that the late HIV-1 accessory protein V...
