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Article
Open AccessRecent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes
In the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts. However, mass productio...
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Article
Statins improve endothelial function via suppression of epigenetic-driven EndMT
The pleiotropic benefits of statins in cardiovascular diseases that are independent of their lipid-lowering effects have been well documented, but the underlying mechanisms remain elusive. Here we show that si...
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Protocol
Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells
Vascular smooth muscle cells (VSMCs), a highly mosaic tissue, arise from multiple distinct embryonic origins and populate different regions of our vascular network with defined boundaries. Accumulating evidenc...
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Protocol
Generation of Quiescent Cardiac Fibroblasts Derived from Human Induced Pluripotent Stem Cells
Myocardial fibrosis is a hallmark of cardiac remodeling, which can progressively lead to heart failure, a leading cause of death worldwide. The effector cells of fibrosis in the heart are cardiac fibroblasts (...
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Article
Open AccessExtracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or endovascular repair (EVAR) is the on...
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Chapter
Remodelling of the Cardiac Extracellular Matrix: Role of Collagen Degradation and Accumulation in Pathogenesis of Heart Failure
The extracellular matrix (ECM) serves a number of functions in every tissue including the myocardium. While the function of ECM as a structural scaffold is well established, it has become increasingly recogniz...
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Article
Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm
An aortic aneurysm is characterized by widening of the aortic lumen diameter with adverse remodelling of the vascular extracellular matrix. A thoracic aortic aneurysm (TAA) is highly prevalent in patients with...
