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Article
Statins improve endothelial function via suppression of epigenetic-driven EndMT
The pleiotropic benefits of statins in cardiovascular diseases that are independent of their lipid-lowering effects have been well documented, but the underlying mechanisms remain elusive. Here we show that si...
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Article
Open AccessAngiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling
Many cell-based therapies are challenged by the poor localization of introduced cells and the use of biomaterial scaffolds with questionable biocompatibility or bio-functionality. Endothelial progenitor cells ...
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Chapter
Imaging Cardiac Stem Cell Therapy
Cardiac stem cell therapy is a promising approach to repair an injured heart. Noninvasive imaging can be tremendously useful for characterizing its therapeutic mechanisms and efficacy. In this chapter, we summ...
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Article
Alternative approaches to generating cardiomyocytes are under development
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Article
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
Human induced pluripotent stem cells (hiPSCs) can now be reprogrammed from different somatic cell sources and differentiated into common cardiovascular cell ty...
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Article
A Titratable Two-Step Transcriptional Amplification Strategy for Targeted Gene Therapy Based on Ligand-Induced Intramolecular Folding of a Mutant Human Estrogen Receptor
The efficacy and safety of cardiac gene therapy depend critically on the level and the distribution of therapeutic gene expression following vector administration. We aimed to develop a titratable two-step tra...
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Article
Non-invasive Bioluminescence Imaging of Myoblast-Mediated Hypoxia-Inducible Factor-1 Alpha Gene Transfer
We tested a novel imaging strategy, in which both the survival of transplanted myoblasts and their therapeutic transgene expression, a recombinant hypoxia-inducible factor-1α (HIF-1α-VP2), can be monitored usi...
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Comparison of Optical Bioluminescence Reporter Gene and Superparamagnetic Iron Oxide MR Contrast Agent as Cell Markers for Noninvasive Imaging of Cardiac Cell Transplantation
In this study, we compared firefly luciferase (Fluc) reporter gene and superparamagnetic iron oxide (Feridex) as cell markers for longitudinal monitoring of cardiomyoblast graft survival using optical biolumin...
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Article
Noninvasive Evaluation of Immunosuppressive Drug Efficacy on Acute Donor Cell Survival
The therapeutic benefits of cell transplantation may depend on the survival of sufficient numbers of grafted cells. We evaluate four potent immunosuppressive medications aimed at preventing acute donor cell de...
