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Open AccessUptake of self-management education programmes for people with type 2 diabetes in primary care through the embedding package: a cluster randomised control trial and ethnographic study
Self-management education programmes are cost-effective in hel** people with type 2 diabetes manage their diabetes, but referral and attendance rates are low. This study reports on the effectiveness of the E...
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Article
Open AccessWhat is the pipeline for future medications for obesity?
Obesity is a chronic disease associated with increased risk of obesity-related complications and mortality. Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appeti...
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Article
Open AccessCirculating sphingolipids and relationship to cardiac remodelling before and following a low-energy diet in asymptomatic Type 2 Diabetes
Heart failure with preserved ejection fraction (HFpEF) is a heterogenous multi-system syndrome with limited efficacious treatment options. The prevalence of Type 2 diabetes (T2D) continues to rise and predispo...
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Article
Open AccessResource efficient aortic distensibility calculation by end to end spatiotemporal learning of aortic lumen from multicentre multivendor multidisease CMR images
Aortic distensibility (AD) is important for the prognosis of multiple cardiovascular diseases. We propose a novel resource-efficient deep learning (DL) model, inspired by the bi-directional ConvLSTM U-Net with...
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Open AccessParticipant and workplace champion experiences of an intervention designed to reduce sitting time in desk-based workers: SMART work & life
A cluster randomised controlled trial demonstrated the effectiveness of the SMART Work & Life (SWAL) behaviour change intervention, with and without a height-adjustable desk, for reducing sitting time in desk-...
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Open AccessIncretins and microvascular complications of diabetes: neuropathy, nephropathy, retinopathy and microangiopathy
Glucagon-like peptide-1 receptor agonists (GLP-1RAs, incretin mimetics) and dipeptidyl peptidase-4 inhibitors (DPP-4is, incretin enhancers) are glucose-lowering therapies with proven cardiovascular safety, but...
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Article
Open AccessSemaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial
In the STEP-HFpEF trial, semaglutide improved symptoms, physical limitations and exercise function and reduced body weight in patients with obesity phenotype of heart failure and preserved ejection fraction (H...
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Article
Open AccessInequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
The aim of this study was to describe the long-term trends in cancer mortality rates in people with type 2 diabetes based on subgroups defined by sociodemographic characteristics and risk factors.
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Sedentary Behaviour, Diabetes and the Metabolic Syndrome
Given the increasing global prevalence of type 2 diabetes (T2DM) and the metabolic syndrome, prevention and management strategies are of the utmost importance. Lifestyle interventions that target increasing le...
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Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on the management of hyperglycaemia in type 2 diabetes in a...
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Open AccessThe impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study
Aerobic exercise training and low energy diets have been shown to improve left ventricular remodelling and diastolic function in adults with type 2 diabetes (T2D), albeit with differential effects. The impact ...
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Open AccessCultural adaptation of a diabetes self-management education and support (DSMES) programme for two low resource urban settings in Ghana, during the COVID-19 era
Type 2 diabetes is a significant public health problem globally and associated with significant morbidity and mortality. Diabetes self-management education and support (DSMES) programmes are associated with im...
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Open AccessCardiovascular outcomes trials: a paradigm shift in the current management of type 2 diabetes
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with type 2 diabetes (T2D). Historical concerns about cardiovascular (CV) risks associated with certain glucose-lowering...
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Open AccessDevice-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study
The number of individuals recovering from severe COVID-19 is increasing rapidly. However, little is known about physical behaviours that make up the 24-h cycle within these individuals. This study aimed to des...
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Open AccessAssociation of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes
Type 2 diabetes (T2D) and hypertension commonly coexist and are associated with subclinical myocardial structural and functional changes. We sought to determine the association between blood pressure (BP) and ...
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Article
Open AccessA population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England
Obesity and ethnicity are known risk factors for COVID-19 outcomes, but their combination has not been extensively examined. We investigate the association between body mass index (BMI) and COVID-19 mortality ...
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Open AccessConsultation rates in people with type 2 diabetes with and without vascular complications: a retrospective analysis of 141,328 adults in England
To assess trends in primary and specialist care consultation rates and average length of consultation by cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), or cardiometabolic multimorbidity exposur...
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Article
Open AccessPromoting inclusion in clinical trials—a rapid review of the literature and recommendations for action
Without inclusion of diverse research participants, it is challenging to understand how study findings will translate into the real world. Despite this, a lack of inclusion of those from under-served groups in...
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Open AccessPatterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.
Pre-existing comorbidities have been linked to SARS-CoV-2 infection but evidence is sparse on the importance and pattern of multimorbidity (2 or more conditions) and severity of infection indicated by hospital...
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Open AccessObesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort
Although age, obesity and pre-existing chronic diseases are established risk factors for COVID-19 outcomes, their interactions have not been well researched.
