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Article
Open AccessLipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy
The metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. However, the processes and mechanisms unde...
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Article
Open AccessShould non-invasive prenatal testing be recommended for patients who achieve pregnancy with PGT?
To determine whether non-invasive prenatal testing is an alternative testing option to preimplantation genetic testing (PGT) in pregnant patients.
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Article
Open AccessFast elimination of emerging contaminates in complicated water environment medium over the resource conversion product of chicken manure biochar triggered by peroxymonosulfate
An innovative strategy for synthesizing novel dual-reaction-center (DRC) catalysts from chicken manure (CM) biochar to purify wastewater that contained emerging contaminants (ECs) is proposed to synchronously ...
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Chapter and Conference Paper
Molecular Dynamics Study on Mechanical Properties of Calcium–Silicate–Hydrate Considering Model and Parameter Effects
The micro and nano scale composition in concrete is one of the essential topics at the moment. At nanoscale, calcium–silicate–hydrate (C–S–H) gel is the main material phase that determines the mechanical prope...
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Article
Cationic Proteins Rich in Lysine Residue Trigger Formation of Non-bilayer Lipid Phases in Model and Biological Membranes: Biophysical Methods of Study
Cationic membrane-active toxins are the most abundant group of proteins in the venom of snakes and insects. Cationic proteins such as cobra venom cytotoxin and bee venom melittin are known for their pharmacolo...
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Article
Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1orf194 Gene Improved CMT-Like Neuropathy in C1orf194-/- Mice
Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor sensory neuropathy, is a group of rare genetically heterogenous diseases characterized by progressive muscle weakness and atrophy, along with s...
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Article
Open AccessCitizenship Practices of Chinese Students on an Australian Campus: a Case Study
This paper explores the citizenship practices of a group of Chinese international students through their engagement with a language club at a university located in Melbourne, Australia. By considering the prac...
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Article
The gain-of-function FAM83H mutation caused hypocalcification amelogenesis imperfecta in a Chinese family
Autosomal-dominant hypocalcification amelogenesis imperfecta (ADHCAI) is a hereditary disease characterized by enamel defects. ADHCAI is mainly caused by nonsense mutations in a gene called family with sequenc...
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Article
Open AccessAuthor Correction: “Dysfunctions” induced by Roux-en-Y gastric bypass surgery are concomitant with metabolic improvement independent of weight loss
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open Access“Dysfunctions” induced by Roux-en-Y gastric bypass surgery are concomitant with metabolic improvement independent of weight loss
Metabolic surgery has been increasingly recommended for obese diabetic patients, but questions remain as to its molecular mechanism that leads to improved metabolic parameters independently of weight loss from...
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Article
Open AccessChronic hepatitis B: dynamic change in Traditional Chinese Medicine syndrome by dynamic network biomarkers
In traditional Chinese medicine (TCM) clinical practice, TCM syndromes help to understand human homeostasis and guide individualized treatment. However, the TCM syndrome changes with disease progression, of wh...
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Article
Open AccessWhole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named “amelin” or “sheathlin”) ...
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Article
Open AccessDynamic network biomarker indicates pulmonary metastasis at the tip** point of hepatocellular carcinoma
Develo** predictive biomarkers that can detect the tip** point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning...
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Chapter and Conference Paper
Improved Ensemble Extreme Learning Machine Regression Algorithm
Compared with other traditional neural network algorithms, the Extreme Learning Machine (ELM) has the advantages of simple structure, fast learning speed and good generalization performance. However, there ar...
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Article
Dysregulated microRNAs involved in the progression of cervical neoplasm
MicroRNAs (miRNAs) exhibit dysregulated expression in human cancer and play an important role in carcinogenesis. The aim of this study was to identify a distinct miRNA expression signature for cervical cancer ...
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Article
Open AccessSystematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia
Genes that regulate stem cell function are suspected to exert adverse effects on prognosis in malignancy. However, diverse cancer stem cell signatures are difficult for physicians to interpret and apply clinic...
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Article
Open AccessEdge biomarkers for classification and prediction of phenotypes
In general, a disease manifests not from malfunction of individual molecules but from failure of the relevant system or network, which can be considered as a set of interactions or edges among molecules. Thus,...
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Article
Open AccessIdentifying critical transitions and their leading biomolecular networks in complex diseases
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucida...
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Article
Open AccessDetecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers
Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt and may cause a critical transition from one state to another at a t...
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Chapter and Conference Paper
A Hybrid Immune Evolutionary Computation Based on Immunity and Clonal Selection for Concurrent Map** and Localization
This paper addresses the problem of Concurrent Map** and Localization(CML) by means of a hybrid immune evolutionary computation based on immunity and clonal selection for a mobile robot. An immune operator, ...
